2-Fluoropyridin-4-ol

Base Information

• Chemical Name: 2-Fluoropyridin-4-ol
• CAS No.: 22282-69-5
• Molecular Formula: C5H4 F N O
• Molecular Weight: 113.091
• Hs Code.: 2933399090
• European Community (EC) Number: 640-434-3
• DSSTox Substance ID: DTXSID60376495
• Wikidata: Q72480059
• Mol file: 22282-69-5.mol

Synonyms:2-Fluoropyridin-4-ol;22282-69-5;2-fluoro-4-hydroxypyridine;2-fluoro-1H-pyridin-4-one;MFCD04114159;2-Fluoro-pyridin-4-ol;253435-42-6;4(1h)-pyridinone,2-fluoro-;SCHEMBL9049241;DTXSID60376495;2-Fluoro-4-hydroxypyridine,97%;BRLSDLHMGRDAPF-UHFFFAOYSA-N;AKOS005255158;AKOS015853577;2-Amino-6-(butylamino)pyrimidin-4-ol;AB17930;CS-W019270;AS-57410;FT-0646026;EN300-216106;A816087;J-509522

Chemical Property of 2-Fluoropyridin-4-ol

Chemical Property:

• Vapor Pressure: 1.13mmHg at 25°C
• Melting Point: 146-149℃
• Refractive Index: 1.508
• Boiling Point: 175.8°Cat760mmHg
• Flash Point: 60.1°C
• PSA: 33.12000
• Density: 1.26g/cm³
• LogP: 0.92630
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 113.027691913
• Heavy Atom Count: 8
• Complexity: 171

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoropyridin-4-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CNC(=CC1=O)F
• Uses: 2-Fluoropyridin-4-ol is a fluoronated pyridine that is used in the synthesis of herbicides and horticultural fungicides.

Technology Process of 2-Fluoropyridin-4-ol

There total 3 articles about 2-Fluoropyridin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-fluoropyridin-4-ylboronic acid (401815-98-3) → 2-fluoropyridin-4-ol (22282-69-5)

Guidance literature:

With trifluoromethylhydrazine; potassium tert-butylate; at 100 ℃; for 10h;

Reference yield: 72.0%

2,4-difluoropyridine (34941-90-7) → 2-fluoropyridin-4-ol (22282-69-5) + 2-hydroxy-4-fluoropyridine (96530-75-5)

Guidance literature:

With 18-crown-6 ether; potassium hydroxide; In neat (no solvent); for 1h; Milling; Sealed tube; Green chemistry;

DOI:10.1039/d1gc04361g

Reference yield:

→ 2-fluoropyridin-4-ol (22282-69-5)

Guidance literature:

2-Fluor-4-amino-pyridin, 1) HNO2, H2SO4, 2) W.;

upstream raw materials:

2-fluoropyridin-4-ylboronic acid

2,4-difluoropyridine

Downstream raw materials:

1-(2-(2,2-difluoroethyl)-8-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)-2-(pyridin-3-yl)propan-2-ol

N-((S)-1-(4-((R)-1-(5-(2,2-difluoroethoxy)pyridin-2-yl)pyrrolidin-3-yloxy)phenyl)ethyl)acetamide

2-chloro-3-(2,2-difluoro-ethoxy)-pyridine

Refernces

• 1、 -. "A catalytic oxidation fragrant boron class compound preparing phenol method (by machine translation)". Paragraph 0073; 0077; 0078. . Retrieved 2017/08/08.