Technology Process of 3-methyl-1-(p-tolylsulfonyl)-[1,3]dioxolo[4,5-f]indazole
There total 5 articles about 3-methyl-1-(p-tolylsulfonyl)-[1,3]dioxolo[4,5-f]indazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate; trans-N,N'-dimethylcyclohexane-1,2-diamine;
In
toluene;
at 20 ℃;
for 2.5h;
Inert atmosphere;
DOI:10.1002/anie.201300917
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: dipyridinium dichromate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere
2.1: copper(ll) bromide / ethyl acetate; chloroform / Inert atmosphere; Reflux
3.1: acetyl chloride; ethanol / Inert atmosphere
3.2: 0.5 h / 20 °C / Inert atmosphere
4.1: potassium carbonate; trans-N,N'-dimethylcyclohexane-1,2-diamine / toluene / 2.5 h / 20 °C / Inert atmosphere
With
dipyridinium dichromate; ethanol; potassium carbonate; trans-N,N'-dimethylcyclohexane-1,2-diamine; acetyl chloride; copper(ll) bromide;
In
chloroform; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1002/anie.201300917
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tetrahydrofuran; diethyl ether / -5 - 20 °C / Inert atmosphere
2.1: dipyridinium dichromate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere
3.1: copper(ll) bromide / ethyl acetate; chloroform / Inert atmosphere; Reflux
4.1: acetyl chloride; ethanol / Inert atmosphere
4.2: 0.5 h / 20 °C / Inert atmosphere
5.1: potassium carbonate; trans-N,N'-dimethylcyclohexane-1,2-diamine / toluene / 2.5 h / 20 °C / Inert atmosphere
With
dipyridinium dichromate; ethanol; potassium carbonate; trans-N,N'-dimethylcyclohexane-1,2-diamine; acetyl chloride; copper(ll) bromide;
In
tetrahydrofuran; diethyl ether; chloroform; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1002/anie.201300917