(R)-(-)-2-phenylbutyric acid chloride

Base Information

• Chemical Name: (R)-(-)-2-phenylbutyric acid chloride
• CAS No.: 105227-22-3
• Molecular Formula: C₁₀H₁₁ClO
• Molecular Weight: 182.65
• Mol file: 105227-22-3.mol

Synonyms:(R)-(-)-2-phenylbutyric acid chloride

Chemical Property of (R)-(-)-2-phenylbutyric acid chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(-)-2-phenylbutyric acid chloride

There total 4 articles about (R)-(-)-2-phenylbutyric acid chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2R)-2-phenylbutanoic acid (938-79-4) → (R)-(-)-2-phenylbutyric acid chloride (105227-22-3)

Guidance literature:

With thionyl chloride; for 1h; Heating;

DOI:10.1016/S0957-4166(97)00636-8

Reference yield:

2-Phenylbutyric acid (90-27-7) → (R)-(-)-2-phenylbutyric acid chloride (105227-22-3)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂SO₄ / 3 h / Heating

2: horse liver esterase, aq. phosphoric buffer / Ambient temperature

3: 100 percent / SOCl₂ / 1 h / Heating

With thionyl chloride; horse liver esterase; phosphoric buffer; sulfuric acid;

DOI:10.1016/S0957-4166(97)00636-8

Reference yield:

2-Phenylbutyric acid (90-27-7) → (S)-(+)-2-phenylbutyric acid chloride (40473-35-6) + (R)-(-)-2-phenylbutyric acid chloride (105227-22-3)

Guidance literature:

2-Phenylbutyric acid; With (R)-1-phenyl-ethyl-amine;

With oxalyl dichloride; at 20 ℃; for 2h;

DOI:10.1080/17415993.2011.580346

upstream raw materials:

(2R)-2-phenylbutanoic acid

methyl 2-phenylbutanoate

2-Phenylbutyric acid

Downstream raw materials:

(S)-2-phenylbutyric acid

(2R)-2-phenylbutanoic acid

(S)-2-Phenyl-butyric acid (S)-1-methyl-heptyl ester

(R)-2-Phenyl-butyric acid (S)-1-methyl-heptyl ester

Refernces

• 1、 Eidamshaus, Christian,Triemer, Therese,Reissig, Hans-Ulrich. "Synthesis of 4-quinolones via cyclocondensation of substituted ortho-amidoacetophenones: A refit to the camps cyclization by applying trimethylsilyl trifluoromethanesulfonate/triethylamine". supporting information; experimental part. p. 3261 - 3266. Retrieved 2011/11/30.
• 2、 Udata, Chandrasekhar,Tirucherai, Giridhar,Mitra, Ashim K.. "Synthesis, stereoselective enzymatic hydrolysis, and skin permeation of diastereomeric propranolol ester prodrugs". . p. 544 - 550. Retrieved 2007/10/03.