C₁₆H₁₂Cl₂O₄

Base Information

• Chemical Name: C₁₆H₁₂Cl₂O₄
• CAS No.: 1440061-23-3
• Molecular Formula: C₁₆H₁₂Cl₂O₄
• Molecular Weight: 339.175
• Mol file: 1440061-23-3.mol

Synonyms:C₁₆H₁₂Cl₂O₄

Chemical Property of C₁₆H₁₂Cl₂O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of C₁₆H₁₂Cl₂O₄

There total 1 articles about C₁₆H₁₂Cl₂O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4'-Dichlorobiphenyl ether (6842-62-2) + Ethyl oxalyl chloride (4755-77-5) → C16H12Cl2O4 (1440061-23-3)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; at 5 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1039/c3nj00032j

Reference yield:

C16H12Cl2O4 (1440061-23-3) → C16H13Cl2NO4 (1440061-93-7)

Guidance literature:

With hydroxylamine hydrochloride; In ethanol; for 5h; Reflux; Inert atmosphere;

DOI:10.1039/c3nj00032j

Reference yield:

C16H12Cl2O4 (1440061-23-3) → 4-(2-chloro-4-(4-chlorophenoxy)phenyl)-2-(2,6-difluorophenyl)-1,3-oxazoline (1440060-55-8)

Guidance literature:

Multi-step reaction with 5 steps

1: hydroxylamine hydrochloride / ethanol / 5 h / Reflux; Inert atmosphere

2: sodium tetrahydroborate; iodine / tetrahydrofuran / 7.5 h / 0 °C / Reflux; Inert atmosphere

3: triethylamine / tetrahydrofuran / 2 h / 5 - 20 °C / Inert atmosphere

4: thionyl chloride / toluene / 3 h / 80 °C / Inert atmosphere

5: sodium hydroxide / methanol / 1 h / 50 °C / Inert atmosphere

With sodium tetrahydroborate; thionyl chloride; hydroxylamine hydrochloride; iodine; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; toluene;

DOI:10.1039/c3nj00032j

upstream raw materials:

3,4'-Dichlorobiphenyl ether

Ethyl oxalyl chloride

Downstream raw materials:

C₁₆H₁₃Cl₂NO₄

4-(2-chloro-4-(4-chlorophenoxy)phenyl)-2-(2,6-difluorophenyl)-1,3-oxazoline

C₂₁H₁₄Cl₃F₂NO₂

C₂₁H₁₅Cl₂F₂NO₃

Refernces