(S)-1-Benzyl-3-N-Boc-aminopiperidine

Base Information

• Chemical Name: (S)-1-Benzyl-3-N-Boc-aminopiperidine
• CAS No.: 454713-13-4
• Molecular Formula: C17H26N2O2
• Molecular Weight: 290.406
• Hs Code.: 29333990
• Mol file: 454713-13-4.mol

Synonyms:(R)1-Benzyl-3-[(tert-butoxycarbonyl)amino]piperidine;

Chemical Property of (S)-1-Benzyl-3-N-Boc-aminopiperidine

Chemical Property:

• Vapor Pressure: 1.23E-06mmHg at 25°C
• Refractive Index: 1.542
• Boiling Point: 400.9 °C at 760 mmHg
• PKA: 12.31±0.20(Predicted)
• Flash Point: 196.2 °C
• PSA: 41.57000
• Density: 1.07 g/cm³
• LogP: 3.50450
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

(R)-tert-Butyl 1-benzylpiperidin-3-ylcarbamate 95% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-1-Benzyl-3-N-Boc-aminopiperidine

There total 15 articles about (S)-1-Benzyl-3-N-Boc-aminopiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

di-tert-butyl dicarbonate (24424-99-5) + (3R)-1-benzyl-3-aminopiperidine (168466-84-0) → tert-butyl (R)-(+)-(N-benzylpiperidin-3-yl)carbamate (454713-13-4,216854-24-9)

Guidance literature:

With sodium hydroxide; In water; at 20 ℃; for 2h;

Reference yield: 88.0%

(R)-2-tert-butyloxycarbonylamino-1,5-pentanedimethanesulfonate + aniline (62-53-3) → tert-butyl (R)-(+)-(N-benzylpiperidin-3-yl)carbamate (454713-13-4,216854-24-9)

Guidance literature:

at 45 ℃; for 2h;

Reference yield:

(R)-piperidin-3-ylcarbamic acid tert-butyl ester (309956-78-3,172603-05-3) + benzaldehyde (100-52-7) → tert-butyl (R)-(+)-(N-benzylpiperidin-3-yl)carbamate (454713-13-4,216854-24-9)

Guidance literature:

(R)-piperidin-3-ylcarbamic acid tert-butyl ester; benzaldehyde; With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃;

With water; potassium carbonate; In methanol;

upstream raw materials:

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

benzaldehyde

benzyl bromide

3-(tert-butoxycarbonylamino)pyridine

Downstream raw materials:

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

(R)-2-(3,5-dichlorophenylamino)-1-(3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)ethanone

(R)-1-benzyl-N-methylpiperidine-3-amine

N-(1-benzylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Refernces

• 1、 -. "JANUS KINASE 1 SELECTIVE INHIBITOR AND PHARMACEUTICAL USE THEREOF". Paragraph 0271-0278. . Retrieved 2018/06/07.
• 2、 -. "Amino-protected (R) - 3-amino-piperidine preparation method". . . Retrieved 2017/03/18.