(R)-3-Boc-aminopiperidine

Base Information Edit

Chemical Name:(R)-3-Boc-aminopiperidine
CAS No.:309956-78-3
Molecular Formula:C10H20N2O2
Molecular Weight:200.281
Hs Code.:29333990
European Community (EC) Number:685-989-2
DSSTox Substance ID:DTXSID30363796
Nikkaji Number:J3.152.624H
ChEMBL ID:CHEMBL4568646
Mol file:309956-78-3.mol

Synonyms:(R)-3-Boc-aminopiperidine;309956-78-3;(R)-3-(Boc-Amino)piperidine;(r)-tert-butyl piperidin-3-ylcarbamate;tert-butyl N-[(3R)-piperidin-3-yl]carbamate;tert-butyl (R)-piperidin-3-ylcarbamate;(r)-piperidin-3-yl-carbamic acid tert-butyl ester;R-3-(Boc-amino)piperidine;(r)-3-(tert-butoxycarbonylamino)piperidine;(r)-3-(boc-amino)-piperidine;(R)-3-tert-butoxycarbonylaminopiperidine;Carbamic acid, (3R)-3-piperidinyl-, 1,1-dimethylethyl ester;MFCD03093382;(R)-(+)-3-tert-Butoxycarbonylaminopiperidine;(R)-3-Bocaminopiperidine;(r)-3-boc-amino piperidine;SCHEMBL219191;(R)-3-N-Boc-amino piperidine;CHEMBL4568646;DTXSID30363796;CS-D0017;STR09306;(R)-3-(Boc-amino)piperidine, 97%;(r)-tert-butylpiperidin-3-ylcarbamate;AKOS005145922;AKOS005258528;tert-butyl(r)-piperidin-3-ylcarbamate;(R)-tert-butyl piperdin-3-ylcarbamate;AC-2189;CS-O-31218;PS-9380;tert-butyl (3R)-piperidin-3-ylcarbamate;tert-butyl (R)-piperidin-3-yl-carbamate;(3R)-3-Aminopiperidine, 3-BOC protected;A5636;AM20090436;B3591;(R)-3-(tert.-butyloxycarbonylamino)-piperidine;1,1-dimethylethyl (3R)-3-piperidinylcarbamate;EN300-172939;(R)-piperidin-3-ylcarbamic acid tert-butyl ester;piperidin-3-(R)-yl-carbamic acid tert-butyl ester;Z1203162349;(R)-3-tert-Butoxycarbonylaminopiperidine, tert-Butyl (R)-piperidin-3-ylcarbamate

Suppliers and Price of (R)-3-Boc-aminopiperidine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-3-(Boc-amino)piperidine
1g
$ 50.00

TRC
(R)-3-(Boc-amino)piperidine
50g
$ 385.00

TCI Chemical
(R)-3-(tert-Butoxycarbonylamino)piperidine >98.0%(GC)(T)
5g
$ 153.00

TCI Chemical
(R)-3-(tert-Butoxycarbonylamino)piperidine >98.0%(GC)(T)
1g
$ 45.00

Sigma-Aldrich
(R)-3-(Boc-amino)piperidine 97%
1g
$ 58.70

Matrix Scientific
(R)-3-Boc-Aminopiperidine 95+%
5g
$ 23.00

Matrix Scientific
(R)-3-Boc-Aminopiperidine 95+%
25g
$ 89.00

JR MediChem
(R)-3-(Boc-Amino)piperidine 98%
10kg
$ 9800.00

JR MediChem
(R)-3-(Boc-Amino)piperidine 98%
500g
$ 880.00

JR MediChem
(R)-3-(Boc-Amino)piperidine 98%
1kg
$ 1480.00

Total 251 raw suppliers

Chemical Property of (R)-3-Boc-aminopiperidine Edit

Chemical Property:

Vapor Pressure:0.000854mmHg at 25°C
Melting Point:121.0 to 125.0 °C
Refractive Index:1.479
Boiling Point:304.8 °C at 760 mmHg
PKA:12.37±0.20(Predicted)
Flash Point:138.2 °C
PSA：50.36000
Density:1.02 g/cm³
LogP:1.98280
Storage Temp.:Room temperature.
Solubility.:Soluble in methanol and ethanol.
XLogP3:1.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:200.152477885
Heavy Atom Count:14
Complexity:199

Purity/Quality:

99%min ^*data from raw suppliers

(R)-3-(Boc-amino)piperidine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi,N
Hazard Codes:Xi,N
Statements: 37/38-41-50
Safety Statements: 26-39-61-29-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC1CCCNC1
Isomeric SMILES:CC(C)(C)OC(=O)N[C@@H]1CCCNC1
Chemical Composition and Structure White to off-white solid with specific optical activity. The chemical structure involves a Boc-protected amino group on the piperidine ring.
Category and Use Originated as a synthetic intermediate in pharmaceutical research and development. Developed as a key component of antidiabetic medications like linagliptin. Common organic synthesis intermediate and medicinal chemistry intermediate. Primarily used for the synthesis of drug molecules and biologically active molecules, especially inhibitors of dipeptidyl peptidase-4 (DPP-4), such as alogliptin and linagliptin. Also a key synthetic intermediate for the drug molecule linagliptin tablets, which lower blood sugar. Inhibits DPP-4, an enzyme involved in glucose regulation, leading to lower blood sugar levels.
Production Methods Two main process routes: one using d-glutamic acid as starting material and the other using 3-hydroxypiperidine. Each route involves several steps including esterification, reduction, and protection reactions.

Technology Process of (R)-3-Boc-aminopiperidine

There total 24 articles about (R)-3-Boc-aminopiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 454713-13-4,216854-24-9
tert-butyl (R)-(+)-(N-benzylpiperidin-3-yl)carbamate

: 309956-78-3,172603-05-3
(R)-piperidin-3-ylcarbamic acid tert-butyl ester

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; In ethanol; at 20 - 25 ℃; for 20h; under 150015 Torr;

Reference yield: 95.4%

: 485820-12-0
(R)-3-(tert-butoxycarbonylamino)piperidine-1-carboxylic acid benzyl ester

: 309956-78-3,172603-05-3
(R)-piperidin-3-ylcarbamic acid tert-butyl ester

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; water; at 35 - 40 ℃; for 2h; under 2250.23 - 3000.3 Torr; Time; Autoclave; Inert atmosphere;

Reference yield: 84.0%

: 221874-51-7
(3R)-3-[(tert -butoxycarbonyl)amino]-2-piperidone

: 309956-78-3,172603-05-3
(R)-piperidin-3-ylcarbamic acid tert-butyl ester

Guidance literature:: (3R)-3-[(tert -butoxycarbonyl)amino]-2-piperidone; With methyl trifluoromethanesulfonate; In dichloromethane; at 25 ℃; for 4h;

With platinum on carbon; hydrogen; In methanol; at 25 ℃; for 4h; under 3750.38 Torr; Autoclave;
DOI:10.1055/a-1526-7657