(S)-1-(3,4-Dimethoxyphenyl)ethylamine

Base Information

• Chemical Name: (S)-1-(3,4-Dimethoxyphenyl)ethylamine
• CAS No.: 65451-89-0
• Molecular Formula: C10H15 N O2
• Molecular Weight: 181.235
• Hs Code.: 2922299090
• Mol file: 65451-89-0.mol

Synonyms:Benzenemethanamine,3,4-dimethoxy-a-methyl-,(S)-; (S)-1-(3,4-Dimethoxyphenyl)ethylamine

Chemical Property of (S)-1-(3,4-Dimethoxyphenyl)ethylamine

Chemical Property:

• Vapor Pressure: 0.00623mmHg at 25°C
• Boiling Point: 272°C at 760 mmHg
• PKA: 9.18±0.10(Predicted)
• Flash Point: 128.2°C
• PSA: 44.48000
• Density: 1.037g/cm³
• LogP: 2.42380
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

(S)-1-(3,4-Dimethoxyphenyl)ethanamine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34-52
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-1-(3,4-Dimethoxyphenyl)ethylamine

There total 3 articles about (S)-1-(3,4-Dimethoxyphenyl)ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(S)-2-{(S)-[1-(3,4-dimethoxyphenyl)ethyl]amino}-3-methylbutan-1-ol (1010385-16-6) → (S)-1-(3',4'-dimethoxyphenyl)ethylamine (65451-89-0)

Guidance literature:

(S)-2-{(S)-[1-(3,4-dimethoxyphenyl)ethyl]amino}-3-methylbutan-1-ol; With periodic acid; methylamine; In methanol; water; at 20 ℃; for 3h;

With hydrogenchloride; In methanol; for 0.5h; Further stages.;

DOI:10.1016/j.tetasy.2007.11.014

Reference yield: 24.0%

1-(3',4'-Dimethoxyphenyl)ethylamine (50919-08-9) + isopropyl 2-propoxyacetate (1121583-62-7) → (R)-2-propoxy-N-(1-(3,4-dimethoxyphenyl)ethyl)acetamide + (S)-1-(3',4'-dimethoxyphenyl)ethylamine (65451-89-0)

Guidance literature:

With lipase B from Candida antarctica immobilized on acrylic beads; In toluene; at 30 ℃; for 8h; enantioselective reaction; Resolution of racemate; Enzymatic reaction;

DOI:10.1016/j.tet.2018.05.032

Reference yield:

diallyl-[1-(S)-(3,4-dimethoxyphenyl)ethyl]amine (944256-03-5) → (S)-1-(3',4'-dimethoxyphenyl)ethylamine (65451-89-0)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,3-dimethylbarbituric acid; triphenylphosphine; In dichloromethane; for 3h; Reflux;

DOI:10.1021/jm900683d

upstream raw materials:

diallyl-[1-(S)-(3,4-dimethoxyphenyl)ethyl]amine

(S)-2-{(S)-[1-(3,4-dimethoxyphenyl)ethyl]amino}-3-methylbutan-1-ol

1-(3',4'-Dimethoxyphenyl)ethylamine

isopropyl 2-propoxyacetate

Downstream raw materials:

[(S)-1-(3,4-dimethoxyphenyl)ethyl]carbamic acid methyl ester

C₁₈H₁₇NO₅

Refernces

• 1、 Lawson, Edward C.,Luci, Diane K.,Ghosh, Shyamali,Kinney, William A.,Reynolds, Charles H.,Qi, Jenson,Smith, Charles E.,Wang, Yuanping,Minor, Lisa K.,Haertlein, Barbara J.,Parry, Tom J.,Damiano, Bruce P.,Maryanoff, Bruce E.. "Nonpeptide urotensin-II receptor antagonists: A new ligand class based on piperazino-phthalimide and piperazino-isoindolinone subunits". experimental part. p. 7432 - 7445. Retrieved 2010/06/19.
• 2、 -. "UROTENSIN II RECEPTOR ANTAGONISTS". Page/Page column 203. . Retrieved 2010/11/28.