(R)-1-N-Boc-2-(hydroxymethyl)piperazine

Base Information

• Chemical Name: (R)-1-N-Boc-2-(hydroxymethyl)piperazine
• CAS No.: 169448-87-7
• Molecular Formula: C10H20N2O3
• Molecular Weight: 216.28
• Hs Code.: 2933599090
• Mol file: 169448-87-7.mol

Synonyms:(R)-2-(Hydroxymethyl)piperazine-1-carboxylic acid tert-butyl ester;1-Piperazinecarboxylicacid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (R)-;(R)-tert-Butyl 2-(hydroxymethyl)piperazine-1-carboxylate;

Chemical Property of (R)-1-N-Boc-2-(hydroxymethyl)piperazine

Chemical Property:

• Vapor Pressure: 1.98E-05mmHg at 25°C
• Refractive Index: 1.477
• Boiling Point: 324 °C at 760 mmHg
• PKA: 14.97±0.10(Predicted)
• Flash Point: 149.7 °C
• PSA: 61.80000
• Density: 1.085 g/cm³
• LogP: 0.45430
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl (2R)-2-(hydroxymethyl)piperazine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (R)-tert-Butyl 2-(hydroxymethyl)piperazine-1-carboxylate is used in preparation of novel substituted quinoline-8-carbonitrile derivatives with androgen receptor degradation activity and uses thereof.

Technology Process of (R)-1-N-Boc-2-(hydroxymethyl)piperazine

There total 6 articles about (R)-1-N-Boc-2-(hydroxymethyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(tert-butyl) 2-methyl (R)-piperazine-1,2-dicarboxylate (252990-05-9) → (R)-2-(hydroxymethyl)piperazine-1-carboxylic acid tert-butyl ester (169448-87-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -40 - 20 ℃; for 1h;

Reference yield: 92.1%

(R)-tert-butyl4-benzyl-2-(hydroxymethyl)piperazine-1-carboxylate (1257855-72-3,947275-34-5) → (R)-2-(hydroxymethyl)piperazine-1-carboxylic acid tert-butyl ester (169448-87-7)

Guidance literature:

With palladium on activated charcoal; hydrogen; palladium(II) hydroxide; acetic acid; In methanol; at 20 ℃;

Reference yield:

(R)-4-benzyl 1-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate (930782-89-1,557056-07-2) → (R)-2-(hydroxymethyl)piperazine-1-carboxylic acid tert-butyl ester (169448-87-7)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 4h;

upstream raw materials:

1-(tert-butyl) 2-methyl (R)-piperazine-1,2-dicarboxylate

(R)-4-benzyl 1-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate

(+)-(2S)-methyl 2-(2-chloroacetylamino)-3-hydroxypropanoate

(S)-3-(hydroxymethyl)-1-(phenylmethyl)-2,5-piperazinedione

Downstream raw materials:

C₃₀H₄₁N₅O₃

(S)-tert-butyl 4-(3-((R)-1-(2,4-dichlorophenyl)ethylamino)-4-nitrophenyl)-2-(hydroxymethyl)piperazine-1-carboxylate

(S)-tert-butyl 4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-indazol-6-yl)-2-(hydroxymethyl)piperazine-1-carboxylate

Refernces

• 1、 -. "Fluorine-substituted monocarbazole derivative as well as preparation method and application thereof (by machine translation)". . . Retrieved 2020/06/20.
• 2、 -. "QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS". Page/Page column 136. . Retrieved 2008/06/13.