(2R,4S)-4-fluoropyrrolidine-2-carboxylic acid

Base Information

• Chemical Name: (2R,4S)-4-fluoropyrrolidine-2-carboxylic acid
• CAS No.: 131176-02-8
• Molecular Formula: C₅H₈FNO₂
• Molecular Weight: 133.122
• Hs Code.: 2933998090
• DSSTox Substance ID: DTXSID20427477
• Mol file: 131176-02-8.mol

Synonyms:(2R,4S)-4-fluoropyrrolidine-2-carboxylic acid;131176-02-8;D-Proline, 4-fluoro-, trans-;MFCD07366527;trans-4-Fluoropyrrolidine-2-carboxylic acid;trans-4-Fluoro-D-proline;Trans-4-fluoropyrrolidine-2-carboxylic acid hcl;SCHEMBL900297;DTXSID20427477;ZIWHMENIDGOELV-IUYQGCFVSA-N;AMY13641;AKOS005063934;AC-2248;AS-34033;CS-0001913;(2R,4S)-4-fluoropyrrolidine-2-carboxylicacid;A26504;A26506;EN300-261281;(2R-trans)-4-fluoro-2-pyrrolidinecarboxylic acid;J-501001

Chemical Property of (2R,4S)-4-fluoropyrrolidine-2-carboxylic acid

Chemical Property:

• Vapor Pressure: 0.00271mmHg at 25°C
• Melting Point: 264 °C
• Boiling Point: 265.1°Cat760mmHg
• Flash Point: 114.1°C
• PSA: 49.33000
• Density: 1.3g/cm³
• LogP: 0.09980
• Storage Temp.: 2-8°C
• XLogP3: -2.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 133.05390666
• Heavy Atom Count: 9
• Complexity: 128

Purity/Quality:

98%,99%, ^*data from raw suppliers

(2R,4S)-4-Fluoropyrrolidine-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(CNC1C(=O)O)F
• Isomeric SMILES: C1[C@@H](CN[C@H]1C(=O)O)F

Technology Process of (2R,4S)-4-fluoropyrrolidine-2-carboxylic acid

There total 9 articles about (2R,4S)-4-fluoropyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

(5S,7R)-7-fluoro-2,2-bis(trifluoromethyl)-1-aza-3-oxabicyclo<3.3.0>octan-4-one (156046-04-7) → (2S,4R)-4-fluoropyrrolidine-2-carboxylic acid (2438-57-5,2507-61-1,7553-49-3,21156-44-5,21156-75-2,60828-35-5,131176-02-8,913820-71-0)

Guidance literature:

With water; In isopropyl alcohol; Ambient temperature;

DOI:10.1016/0022-1139(93)02907-V

Reference yield:

L-4-hydroxyproline methyl ester hydrochloride (40216-83-9) → (2S,4R)-4-fluoropyrrolidine-2-carboxylic acid (2438-57-5,2507-61-1,7553-49-3,21156-44-5,21156-75-2,60828-35-5,131176-02-8,913820-71-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 76 percent / Et₃N / CHCl₃ / 0 °C

2: 1.) PPh₃, DEAD, PhCO₂H; 2.) KOH / 1.) toluene; 2.) MeOH

3: 63 percent / DAST / CH₂Cl₂ / -78 deg C to r.t.

4: 99 percent / LiOH / acetonitrile; H₂O / Ambient temperature

5: TFA / CH₂Cl₂

With potassium hydroxide; lithium hydroxide; triethylamine; triphenylphosphine; 4,4'-diaminostilbene-2,2'-disulfonic acid; benzoic acid; trifluoroacetic acid; diethylazodicarboxylate; In dichloromethane; chloroform; water; acetonitrile;

DOI:10.1016/S0040-4039(97)10793-6

Reference yield:

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-fluoropyrrolidine-2-carboxylic acid (203866-14-2) → (2S,4R)-4-fluoropyrrolidine-2-carboxylic acid (2438-57-5,2507-61-1,7553-49-3,21156-44-5,21156-75-2,60828-35-5,131176-02-8,913820-71-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/S0040-4039(97)10793-6

upstream raw materials:

(5S,7R)-7-fluoro-2,2-bis(trifluoromethyl)-1-aza-3-oxabicyclo<3.3.0>octan-4-one

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-fluoropyrrolidine-2-carboxylic acid

(6S,7aS)-6-hydroxy-3,3-bis(trifluoromethyl)tetrahydro-pyrrolo[1,2-c]oxazol-1-one

hydroxy L-proline

Downstream raw materials:

(2S,4R)-N-Fmoc-4-fluoroproline

(2S,4R)-N-methyl-4-fluoropyrrolidine-2-carboxylic acid hydrochloride

1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-{(1S,4R)-4-[3-((2S,4R)-4-fluoro-1-methyl-pyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea

Refernces

• 1、 Hamacher, Kurt. "Synthesis of n.c.a. cis- and trans-4-[18F]fluoro-L-proline, radiotracers for PET-investigation of disordered matrix protein synthesis". . p. 1135 - 1144. Retrieved 2007/10/03.
• 2、 Burger, Klaus,Rudolph, Martin,Fehn, Susanna,Sewald, Norbert. "Synthesis of (2S)-4,4-difluoroproline, (2S,4R)-4-fluoroproline and their derivatives from (S)-aspartic acid". . p. 87 - 90. Retrieved 2007/10/02.