Technology Process of methyl (R)-3-benzyloxyoctadecanoate
There total 2 articles about methyl (R)-3-benzyloxyoctadecanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(R)-β-hydroxyoctadecanoic acid methyl ester; benzaldehyde;
With
Hexamethyldisiloxane; trimethylsilyl trifluoromethanesulfonate;
In
tetrahydrofuran;
at -20 - 0 ℃;
for 2h;
Inert atmosphere;
With
triethylsilane;
In
tetrahydrofuran;
for 1h;
Inert atmosphere;
DOI:10.1002/chem.201003581
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: dichloro-R-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl ruthenium; hydrogen / methanol / 16 h / 60 °C / Inert atmosphere
2.1: Hexamethyldisiloxane; trimethylsilyl trifluoromethanesulfonate / tetrahydrofuran / 2 h / -20 - 0 °C / Inert atmosphere
2.2: 1 h / Inert atmosphere
With
dichloro-R-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl ruthenium; Hexamethyldisiloxane; trimethylsilyl trifluoromethanesulfonate; hydrogen;
In
tetrahydrofuran; methanol;
DOI:10.1002/chem.201003581
- Guidance literature:
-
methyl (R)-3-benzyloxyoctadecanoate;
With
lithium hydroxide monohydrate;
In
tetrahydrofuran; methanol; water;
at 20 ℃;
for 6h;
With
hydrogenchloride;
In
tetrahydrofuran; methanol; water;
DOI:10.1002/chem.201003581
