Technology Process of (R)-3-(benzyloxy)octadecanoic acid
There total 3 articles about (R)-3-(benzyloxy)octadecanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl (R)-3-benzyloxyoctadecanoate;
With
lithium hydroxide monohydrate;
In
tetrahydrofuran; methanol; water;
at 20 ℃;
for 6h;
With
hydrogenchloride;
In
tetrahydrofuran; methanol; water;
DOI:10.1002/chem.201003581
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: dichloro-R-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl ruthenium; hydrogen / methanol / 16 h / 60 °C / Inert atmosphere
2.1: Hexamethyldisiloxane; trimethylsilyl trifluoromethanesulfonate / tetrahydrofuran / 2 h / -20 - 0 °C / Inert atmosphere
2.2: 1 h / Inert atmosphere
3.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 6 h / 20 °C
With
dichloro-R-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl ruthenium; lithium hydroxide monohydrate; Hexamethyldisiloxane; trimethylsilyl trifluoromethanesulfonate; hydrogen;
In
tetrahydrofuran; methanol; water;
DOI:10.1002/chem.201003581
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: Hexamethyldisiloxane; trimethylsilyl trifluoromethanesulfonate / tetrahydrofuran / 2 h / -20 - 0 °C / Inert atmosphere
1.2: 1 h / Inert atmosphere
2.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 6 h / 20 °C
With
lithium hydroxide monohydrate; Hexamethyldisiloxane; trimethylsilyl trifluoromethanesulfonate;
In
tetrahydrofuran; methanol; water;
DOI:10.1002/chem.201003581
