3-Amino-6-chloropyridine-2-carbonitrile

Base Information

• Chemical Name: 3-Amino-6-chloropyridine-2-carbonitrile
• CAS No.: 95095-84-4
• Molecular Formula: C6H4ClN3
• Molecular Weight: 153.571
• Hs Code.: 2933399090
• Mol file: 95095-84-4.mol

Synonyms:3-Amino-6-chloropyridine-2-carbonitrile;

Chemical Property of 3-Amino-6-chloropyridine-2-carbonitrile

Chemical Property:

• Vapor Pressure: 9.67E-06mmHg at 25°C
• Melting Point: 175-176.5 °C(Solv: ethanol (64-17-5))
• Refractive Index: 1.615
• Boiling Point: 372.4 °C at 760 mmHg
• PKA: -0.85±0.10(Predicted)
• Flash Point: 179 °C
• PSA: 62.70000
• Density: 1.427 g/cm³
• LogP: 1.77008

Purity/Quality:

99% ^*data from raw suppliers

3-Amino-6-chloropyridine-2-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Amino-6-chloropyridine-2-carbonitrile

There total 4 articles about 3-Amino-6-chloropyridine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.42%

6-chloro-3-nitropicolinonitrile (93683-65-9) → 3-amino-6-chloro-pyridine-2-carbonitrile (95095-84-4)

Guidance literature:

6-chloro-3-nitropicolinonitrile; With hydrogenchloride; iron; In ethanol; water; for 0.5h; Reflux;

With ammonia; In diethyl ether; ethanol;

Reference yield: 58.0%

2,6-dicholoro-3-nitropyridine (16013-85-7,136901-10-5) + iron (7439-89-6) → 3-amino-6-chloro-pyridine-2-carbonitrile (95095-84-4)

Guidance literature:

With hydrogenchloride; In methanol; water;

Reference yield:

2,6-dicholoro-3-nitropyridine (16013-85-7,136901-10-5) → 3-amino-6-chloro-pyridine-2-carbonitrile (95095-84-4)

Guidance literature:

Multi-step reaction with 2 steps

1: NMP / 180 °C

2: Fe, HCl / methanol

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; iron; In methanol;

DOI:10.1021/jm980206z

upstream raw materials:

6-chloro-3-nitropicolinonitrile

2,6-dicholoro-3-nitropyridine

iron

2,6-dichloropyridine

Downstream raw materials:

3-amino-6-chloro-pyridine-2-carboxylic acid amide

6-chloropyrido[3,2-d]pyrimidin-4-amine

3-amino-6-chloro-pyridine-2-carbaldehyde

3-amino-6-chloro-pyridine-2-carboxylic acid

Refernces

• 1、 -. "4, 6-disubstituted pyridine [3, 2-d] pyrimidine compound as well as preparation and application thereof". Paragraph 0128-0201. . Retrieved 2020/04/02.
• 2、 -. "Cyclohexylpropionic polypyridine deriv.". Paragraph 0061. . Retrieved 2016/10/27.