2,6-Dichloropyridine

Base Information

• Chemical Name: 2,6-Dichloropyridine
• CAS No.: 2402-78-0
• Molecular Formula: C5H3Cl2N
• Molecular Weight: 147.992
• Hs Code.: 2933.39
• European Community (EC) Number: 219-282-3
• NSC Number: 76606
• UNII: WM26PC2SBW
• DSSTox Substance ID: DTXSID2051895
• Nikkaji Number: J51.304K
• Wikipedia: 2,6-Dichloropyridine
• Wikidata: Q72467879
• ChEMBL ID: CHEMBL3561947
• Mol file: 2402-78-0.mol

Synonyms:2,6-dichloropyridine

Chemical Property of 2,6-Dichloropyridine

Chemical Property:

• Appearance/Colour: White to light yellow solid
• Vapor Pressure: 0.349mmHg at 25°C
• Melting Point: 83-86 °C(lit.)
• Refractive Index: 1.553
• Boiling Point: 206 °C at 760 mmHg
• PKA: -3.02±0.10(Predicted)
• Flash Point: 97.5 °C
• PSA: 12.89000
• Density: 1.388 g/cm³
• LogP: 2.38840
• Storage Temp.: Store below +30°C.
• Solubility.: methanol: 50 mg/mL, clear
• Water Solubility.: <1 g/L (20℃)
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 146.9642545
• Heavy Atom Count: 8
• Complexity: 68.8

Purity/Quality:

99% ^*data from raw suppliers

2,6-Dichloropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T,Xn
• Hazard Codes: T,Xn
• Statements: 25-36/37/38-22-23/24/25
• Safety Statements: 36/37/39-45-37/39-26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Pyridines
• Canonical SMILES: C1=CC(=NC(=C1)Cl)Cl
• Uses: 2,6-Dichloropyridine is used in the preparation of triazolo and imidazo potassium channel antagonists as antiarrythmic agents.

Technology Process of 2,6-Dichloropyridine

There total 24 articles about 2,6-Dichloropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.05%

2-chloropyridine (109-09-1) → 2,6-dichloropyridine (2402-78-0)

Guidance literature:

With chlorine; at 100 - 150 ℃; Temperature; UV-irradiation; Large scale;

Reference yield: 94.0%

2,6-dichloropyridine N-oxide (2587-00-0) → 2,6-dichloropyridine (2402-78-0)

Guidance literature:

With 2-methyl-but-2-ene; trans-dioxo(5,10,15,20-tetramesitylporphirinato)ruthenium(VI); In benzene; at 30 ℃; for 15h;

DOI:10.1248/cpb.46.1656

Reference yield: 89.0%

pyridine (110-86-1) → 2,6-dichloropyridine (2402-78-0)

Guidance literature:

With chlorine; at 170 ℃; for 0.00666667h; Temperature; Inert atmosphere; Irradiation;

upstream raw materials:

pyridine

6-chloro-2-hydroxypyridine

2,6-dichloro-isonicotinic acid ; silver (I)-compound

2-chloropyridine

Downstream raw materials:

6-chloropyridin-2-amine

2,6-dichloropyridine-4-carbaldehyde

2,6-dichloro-pyridine-3-carbaldehyde

6-chloro-2-methoxypyridine

Refernces

• 1、 An, Ju Hyeon,Kim, Kyu Dong,Lee, Jun Hee. "Highly Chemoselective Deoxygenation of N-Heterocyclic N-Oxides Using Hantzsch Esters as Mild Reducing Agents". supporting information. p. 2876 - 2894. Retrieved 2021/02/01.
• 2、 Cardinale, Luana,Jacobi Von Wangelin, Axel,Konev, Mikhail O.. "Catalyst-Free N-Deoxygenation by Photoexcitation of Hantzsch Ester". supporting information. . Retrieved 2020/02/15.