2-Chloro-6-methoxypyridine

Base Information

• Chemical Name: 2-Chloro-6-methoxypyridine
• CAS No.: 17228-64-7
• Molecular Formula: C6H6ClNO
• Molecular Weight: 143.573
• Hs Code.: 29333990
• European Community (EC) Number: 241-264-9
• DSSTox Substance ID: DTXSID00169247
• Nikkaji Number: J127.301I
• Wikidata: Q63395361
• Mol file: 17228-64-7.mol

Synonyms:2-Chloro-6-methoxypyridine;17228-64-7;Pyridine, 2-chloro-6-methoxy-;6-Chloro-2-methoxypyridine;2-chloro-6-methoxy-pyridine;MFCD00006265;2-Methoxy-6-chloropyridine;EINECS 241-264-9;6-methoxy-2-chloropyridine;2-chloro-6-methoxy pyridine;SCHEMBL336762;2-chloro-6-(methyloxy)pyridine;DTXSID00169247;2-Chloro-6-methoxypyridine, 98%;STR05029;PYRIDINE,2-CHLORO,6-METHOXY;CL0089;AKOS005255626;AB00671;AC-5125;AM62357;CS-W001995;PS-4836;SY015984;A3794;FT-0611872;EN300-71351;J-640103;J-800105;W-107867;Q63395361

Chemical Property of 2-Chloro-6-methoxypyridine

Chemical Property:

• Appearance/Colour: Colorless to pale yellow liquid
• Vapor Pressure: 0.832mmHg at 25°C
• Refractive Index: n20/D 1.528(lit.)
• Boiling Point: 188.3 °C at 760 mmHg
• PKA: 0.40±0.10(Predicted)
• Flash Point: 76.1 °C
• PSA: 22.12000
• Density: 1.21 g/cm³
• LogP: 1.74360
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 143.0137915
• Heavy Atom Count: 9
• Complexity: 89.1

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-6-methoxy-pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=NC(=CC=C1)Cl
• Uses: 2-Chloro-6-methoxy-pyridine is a reagent used to synthesize imidazo[1,2-a]pyrimidines as functionally selective GABAA ligands. It can also be used to synthesize oxazolidinedione-arylpyridinones as EP3 receptor antagonists.

Technology Process of 2-Chloro-6-methoxypyridine

There total 8 articles about 2-Chloro-6-methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,6-dichloropyridine (2402-78-0) + methanol (67-56-1) → 6-chloro-2-methoxypyridine (17228-64-7)

Guidance literature:

With sodium methylate; at 20 - 60 ℃; for 24h;

DOI:10.1248/cpb.c16-00009

Reference yield: 100.0%

2,6-dichloropyridine (2402-78-0) + sodium methylate (124-41-4) → 6-chloro-2-methoxypyridine (17228-64-7)

Guidance literature:

In methanol; at 60 ℃; for 24h;

DOI:10.1021/ol500529w

Reference yield: 95.9%

→ 6-chloro-2-methoxypyridine (17228-64-7)

Guidance literature:

upstream raw materials:

2,6-dichloropyridine

methanol

sodium methylate

6-chloro-2-pyridone

Downstream raw materials:

2-(benzyloxy)-6-methoxypyridine

6'-methoxy-5-methyl-2,2'-bipyridine

C₁₄H₁₃NO₄

2-methoxy-6-(4'-methylphenyl)pyridine

Refernces

• 1、 -. "Synthesis method and aftertreatment process of 6-chloro-2-hydrocarbyloxy pyridine". Paragraph 0036-0038; 0039-0040; 0045-0048; 0059-0061. . Retrieved 2018/06/15.
• 2、 -. "Novel synthesis method for ortho-alkane superseded pyridine". Paragraph 0022; 0023. . Retrieved 2017/07/19.