2-BENZOFURANCARBOXYLIC ACID, ETHYL ESTER

Base Information

• Chemical Name: 2-BENZOFURANCARBOXYLIC ACID, ETHYL ESTER
• CAS No.: 3199-61-9
• Molecular Formula: C11H10O3
• Molecular Weight: 190.199
• Hs Code.: 2932999099
• Mol file: 3199-61-9.mol

Synonyms:Ethyl2-benzofurancarboxylate;Ethyl coumarilate;

Chemical Property of 2-BENZOFURANCARBOXYLIC ACID, ETHYL ESTER

Chemical Property:

• Vapor Pressure: 0.00554mmHg at 25°C
• Melting Point: 166-170℃
• Refractive Index: 1.57
• Boiling Point: 274 °C at 760 mmHg
• Flash Point: 119.5 °C
• PSA: 39.44000
• Density: 1.183 g/cm³
• LogP: 2.60950
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

EthylCoumarilate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl Coumarilate has been used as a reactant for the preparation of benzofuropyridines that have a high affinity for the α2-adrenoceptor.

Technology Process of 2-BENZOFURANCARBOXYLIC ACID, ETHYL ESTER

There total 43 articles about 2-BENZOFURANCARBOXYLIC ACID, ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-benzofurane (271-89-6) + formic acid ethyl ester (109-94-4) → ethyl coumarilate (3199-61-9)

Guidance literature:

1-benzofurane; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 2h;

formic acid ethyl ester; In tetrahydrofuran; hexane; at -78 ℃; for 3h;

With ethanol; iodine; potassium carbonate; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 13h;

DOI:10.1016/j.tet.2012.04.016

Reference yield: 99.0%

ethyl (2-formylphenoxy)acetate (41873-61-4) → ethyl coumarilate (3199-61-9)

Guidance literature:

With P(MeNCH₂CH₂)3N; In ethanol; at 70 ℃; for 3h;

DOI:10.1055/s-2001-13377

Reference yield: 95.0%

salicylaldehyde (90-02-8) + ethyl bromoacetate (105-36-2) → ethyl coumarilate (3199-61-9)

Guidance literature:

With caesium carbonate; In acetonitrile; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1016/j.tet.2010.10.074

upstream raw materials:

Benzofuran-2-carboxylic acid

ethanol

1-benzofurane

carbon monoxide

Downstream raw materials:

benzofuran-2-carboxylic acid N-phenylamide

2-bromomethylbenzofuran

5-(benzofuran-2-yl)-1,3,4-oxadiazole-2-thiol

α,α-diphenyl-2-benzofuranmethanol

Refernces

• 1、 Cardoso, Sandra M.,Chand, Karam,Chaves, Sílvia,Fancellu, Gaia,Orlandini, Elisabetta,Piemontese, Luca,Santos, M. Amélia,Silva, Diana F.,Tomás, Daniel. "Novel tacrine–benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer’s Disease". . p. 211 - 226. Retrieved 2020.
• 2、 Abedinifar, Fahimeh,Farnia, S. Morteza F.,Mahdavi, Mohammad,Nadri, Hamid,Moradi, Alireza,Ghasemi, Jahan B.,Kü?ükk?l?n?, Tuba Tüylü,Firoozpour, Loghman,Foroumadi, Alireza. "Synthesis and cholinesterase inhibitory activity of new 2-benzofuran carboxamide-benzylpyridinum salts". . p. 180 - 188. Retrieved 2018.
• 3、 Bhaskar,Yadav. "Synthesis and biological evaluation of a series of novel benzofuran-2-carboxylate 1,2,3-triazoles". . p. 767 - 774. Retrieved 2021/09/28.
• 4、 Nasier, Abudulajiang,Chang, Xihao,Guo, Chang. "Electrodimerization ofN-Alkoxyamides for the Synthesis of Hydrazines". . p. 16068 - 16076. Retrieved 2021/09/18.