5-FLUORO-2-IODOPYRIDINE

Base Information

• Chemical Name: 5-FLUORO-2-IODOPYRIDINE
• CAS No.: 159870-80-1
• Molecular Formula: C5H3 F I N
• Molecular Weight: 222.988
• Hs Code.: 2933399090
• Mol file: 159870-80-1.mol

Synonyms:5-Fluoro-2-iodopyridine

Chemical Property of 5-FLUORO-2-IODOPYRIDINE

Chemical Property:

• Vapor Pressure: 0.544mmHg at 25°C
• Boiling Point: 197°Cat760mmHg
• PKA: -0.58±0.10(Predicted)
• Flash Point: 72.9°C
• PSA: 12.89000
• Density: 2.046g/cm³
• LogP: 1.82530
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Fluoro-2-iodopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-FLUORO-2-IODOPYRIDINE

There total 2 articles about 5-FLUORO-2-IODOPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

→ 5-fluoro-2-iodopyridine (159870-80-1)

Guidance literature:

With copper(l) iodide; sodium iodide; In 1,4-dioxane; for 0.166667h;

With N,N`-dimethylethylenediamine; In 1,4-dioxane; at 130 ℃; for 18h;

Reference yield:

2-bromo-5-fluoropyridine (41404-58-4) → 5-fluoro-2-iodopyridine (159870-80-1)

Guidance literature:

With copper(I) oxide; L-proline; potassium iodide; In ethanol; at 110 ℃; for 30h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1016/j.cattod.2016.01.050

Reference yield: 49.0%

5-fluoro-2-iodopyridine (159870-80-1) + 1-benzyl-4-iodo-1H-imidazole (536760-32-4) → 2-(1-benzyl-1H-imidazol-4-yl)-5-fluoropyridine

Guidance literature:

1-benzyl-4-iodo-1H-imidazole; With methylmagnesium chloride; In tetrahydrofuran; at -30 - 0 ℃; for 2h;

With Trimethyl borate; In tetrahydrofuran; at -60 - 0 ℃; for 3h;

5-fluoro-2-iodopyridine; With (4-(N,N-dimethylamino)phenyl)-di-tert-butylphosphine; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); CO₄^(3-)*3K⁽¹⁺⁾; palladium diacetate; In 1,4-dioxane; water; at 100 ℃; for 16h;

upstream raw materials:

2-bromo-5-fluoropyridine

Downstream raw materials:

2-ethynyl-5-fluoropyridine

Refernces

• 1、 Feng, Xiujuan,Li, Lingyu,Yu, Xiaoqiang,Yamamoto, Yoshinori,Bao, Ming. "Copper-catalyzed conversion of aryl and heteroaryl bromides into the corresponding iodide". . p. 129 - 132. Retrieved 2016/07/06.