41404-58-4 Usage
Description
2-Bromo-5-fluoropyridine is an organic compound with the molecular formula C5H3BrFN. It is a light yellow crystalline substance that belongs to the pyridine family of heteroaromatic compounds. 2-Bromo-5-fluoropyridine is characterized by the presence of a bromine atom at the 2nd position and a fluorine atom at the 5th position on the pyridine ring.
Uses
1. Used in Pharmaceutical Industry:
2-Bromo-5-fluoropyridine is used as a key intermediate in the synthesis of mGluR5 antagonists, which are important for the treatment of neuropathic pain. These antagonists help in modulating the activity of metabotropic glutamate receptor 5 (mGluR5), a protein that plays a crucial role in the transmission of pain signals in the nervous system.
2. Used in Chemical Synthesis:
2-Bromo-5-fluoropyridine can be employed in various chemical reactions to synthesize different compounds. Some of these reactions include:
a. Suzuki Coupling Reaction:
It can be used in the synthesis of 5-fluoro-2-phenylpyridine by undergoing a Suzuki coupling reaction with phenylboronic acid.
It can also be used in the synthesis of 5-fluoro-2-(p-tolyl)pyridine by undergoing a Suzuki coupling reaction with p-tolylboronic acid.
b. Palladium-Catalyzed Homo-Coupling Reaction:
2-Bromo-5-fluoropyridine can undergo a palladium-catalyzed homo-coupling reaction to give the corresponding biaryl, which is a compound with two pyridine rings connected by a carbon-carbon bond.
c. Palladium-Catalyzed α-Arylation of Esters:
It can be employed in a palladium-catalyzed α-arylation of esters, leading to the formation of 4-pyridylcarboxypiperidines, which are important compounds in the field of medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 41404-58-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,1,4,0 and 4 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 41404-58:
(7*4)+(6*1)+(5*4)+(4*0)+(3*4)+(2*5)+(1*8)=84
84 % 10 = 4
So 41404-58-4 is a valid CAS Registry Number.
InChI:InChI=1/C5H3BrFN/c6-5-2-1-4(7)3-8-5/h1-3H
41404-58-4Relevant articles and documents
PYRROLOPYRIMIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS
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Paragraph 0268, (2016/04/09)
Disclosed are chemical entities of formula I: [INSERT CHEMICAL FORMULA HERE] wherein X, Y, Z, R1, R3, R4, R5 and R6 are defined herein, as NR2B subtype selective receptor antagonists. Also disclosed are pharmaceutical compositions comprising a chemical entity of formula I, and methods of treating various diseases and disorders associated with NR2B antagonism, e.g., diseases and disorders of the CNS, such as depression, by administering a chemical entity of formula I.
Structure-activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 1
Takeuchi, Kumiko,Holloway, William G.,McKinzie, Jamie H.,Suter, Todd M.,Statnick, Michael A.,Surface, Peggy L.,Emmerson, Paul J.,Thomas, Elizabeth M.,Siegel, Miles G.,Matt, James E.,Wolfe, Chad N.,Mitch, Charles H.
, p. 5349 - 5352 (2008/02/13)
A structurally unique and new class of opioid receptor antagonists (OpRAs) that bear no structural resemblance with morphine or endogenous opioid peptides has been discovered. A series of carboxamido-biaryl ethers were identified as potent receptor antagonists against mu, kappa and delta opioid receptors. The structure-activity relationship indicated para-substituted aryloxyaryl primary carboxamide bearing an amine tether on the distal phenyl ring was optimal for potent in vitro functional antagonism against three opioid receptor subtypes.
Method for preparing 2,5-dihalo- and 2,5,6-trihalopyridines
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, (2008/06/13)
A method for preparing 2,5-dihalo- and 2,5,6-trihalopyridines corresponding to the formula SPC1 Wherein each X independently represents chloro, fluoro or bromo and R represents hydrogen, chloro, fluoro or bromo which comprises reacting a halohydrazinopyridine of one of the formulas SPC2 With an excess of an aqueous alkali metal hydroxide in the presence of a reaction medium from the group consisting of loweralkanols of 1 to 4 carbon atoms and loweralkylglycols of 2 to 4 carbon atoms.