4-Cyanopyridazine

Base Information

• Chemical Name: 4-Cyanopyridazine
• CAS No.: 68776-62-5
• Molecular Formula: C5H3N3
• Molecular Weight: 105.099
• Hs Code.: 2933990090
• Mol file: 68776-62-5.mol

Synonyms:4-Cyanopyridazine;

Chemical Property of 4-Cyanopyridazine

Chemical Property:

• Appearance/Colour: white powder
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 68-73 °C
• Refractive Index: 1.541
• Boiling Point: 315.273 °C at 760 mmHg
• PKA: -0.65±0.10(Predicted)
• Flash Point: 113.482 °C
• PSA: 49.57000
• Density: 1.226 g/cm³
• LogP: 0.34828
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

pyridazine-4-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Cyanopyridazine

There total 2 articles about 4-Cyanopyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

cyclohexa-1,4-diene (1165952-92-0) + pyridazine-4,5-dicarbonitrile (17412-15-6) → pyridazine-4-carbonitrile (68776-62-5) + 2,3-dicyano-5,8-dihydronaphthalene

Guidance literature:

In chloroform; at 110 ℃; for 48h;

DOI:10.1021/jo960321m

Reference yield:

→ pyridazine-4-carbonitrile (68776-62-5)

Guidance literature:

4-Carbamoyl-pyridazin, sd. POCl3;

Reference yield: 81.0%

2-mercaptopropanoic acid (79-42-5) + pyridazine-4-carbonitrile (68776-62-5) → 5-Methyl-2-pyridazin-4-yl-thiazol-4-ol (1279105-88-2)

Guidance literature:

With pyridine; at 100 ℃; for 3h;

upstream raw materials:

cyclohexa-1,4-diene

pyridazine-4,5-dicarbonitrile

Downstream raw materials:

trifluoro-methanesulfonic acid 5-methyl-2-pyridazin-4-yl-thiazol-4-yl ester

5-Methyl-2-pyridazin-4-yl-thiazol-4-ol

pyridazine-4-carbothioamide

4-(1 H-tetrazol-5-yl)pyridazine

Refernces

• 1、 -. "NOVEL 1,2,4 OXADIAZOLE COMPOUNDS AND METHODS OF USE THEREOF". Page/Page column 73. . Retrieved 2009/12/28.