N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER

Base Information

• Chemical Name: N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER
• CAS No.: 81167-39-7
• Molecular Formula: C16H15 N O2
• Molecular Weight: 253.301
• Hs Code.: 2925290090
• Mol file: 81167-39-7.mol

Synonyms:(Benzhydrylideneamino)aceticacid methyl ester; Benzophenoneimine glycine methyl ester; Methyl2-[(diphenylmethylene)amino]acetate; Methyl 3-aza-4,4-diphenylbut-3-enoate;Methyl N-(diphenylmethylene)glycinate; Methyl[(diphenylmethylene)amino]acetate; N-(Diphenylmethylene)glycine methyl ester;N-Diphenylmethylideneglycine methyl ester

Chemical Property of N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER

Chemical Property:

• Vapor Pressure: 7.36E-05mmHg at 25°C
• Melting Point: 42-44oC
• Boiling Point: 342.8oC at 760 mmHg
• PKA: 2.22±0.50(Predicted)
• Flash Point: 135.8oC
• PSA: 38.66000
• Density: 1.05g/cm3
• LogP: 2.69700
• Storage Temp.: Refrigerator, Under Inert Atmosphere

Purity/Quality:

99% ^*data from raw suppliers

N-(Diphenylmethylene)glycineMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-(Diphenylmethylene)glycine Methyl Ester (cas# 81167-39-7) is a compound useful in organic synthesis.

Technology Process of N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER

There total 5 articles about N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Benzophenone imine (1013-88-3) + glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) → methyl N-(diphenylmethylene)glycinate (81167-39-7)

Guidance literature:

In dichloromethane; at 20 ℃; for 4h;

DOI:10.1016/S0960-894X(01)00371-7

Reference yield: 70.0%

Benzophenone imine (1013-88-3) + bromoacetic acid methyl ester (96-32-2) → methyl N-(diphenylmethylene)glycinate (81167-39-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 90 ℃; for 12h;

Reference yield: 68.0%

benzophenone (119-61-9) + glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) → methyl N-(diphenylmethylene)glycinate (81167-39-7)

Guidance literature:

With toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In toluene; for 8h; Reflux; Dean-Stark; Inert atmosphere;

DOI:10.1002/ejoc.201601384

upstream raw materials:

Benzophenone imine

glycine ethyl ester hydrochloride

Methyl azidoacetate

Thiobenzophenon

Downstream raw materials:

(benzhydrylidene-amino)-(3-oxo-cyclohexyl)-acetic acid methyl ester

Methyl (2-benzhydrylideneamino-4-methyl) pent-4-enoate

cis methyl N-(diphenyl methylene)-2-carvenyl glycinate

2-(Benzhydrylidene-amino)-3-m-tolyl-propionic acid methyl ester

Refernces

• 1、 Vera, Silvia,Vázquez, Ana,Rodriguez, Ricardo,Pozo, Sandra Del,Urruzuno, I?aki,de Cózar, Abel,Mielgo, Antonia,Palomo, Claudio. "Synthesis of β-Hydroxy α-Amino Acids through Br?nsted Base-Catalyzed syn-Selective Direct Aldol Reaction of Schiff Bases of Glycine o-Nitroanilide". . p. 7757 - 7772. Retrieved 2021/06/21.
• 2、 -. "NOVEL OPIOID ANTAGONISTS AND METHODS RELATED THERETO". Paragraph 0046. . Retrieved 2020/05/14.