TRANS-4-HYDROXY-D-PROLINE HYDROCHLORIDE

Base Information

• Chemical Name: TRANS-4-HYDROXY-D-PROLINE HYDROCHLORIDE
• CAS No.: 142347-81-7
• Molecular Formula: C5H9NO3.HCl
• Molecular Weight: 167.592
• Hs Code.: 2933998090
• Mol file: 142347-81-7.mol

Synonyms:trans-4-Hydroxy-D-proline hydrochloride;

Chemical Property of TRANS-4-HYDROXY-D-PROLINE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 6.22E-07mmHg at 25°C
• Boiling Point: 368.6 °C at 760 mmHg
• Flash Point: 176.7 °C
• PSA: 69.56000
• LogP: -0.07540
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

trans-4-Hydroxy-D-prolineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (trans-4-Hydroxy-D-proline Hydrochloride) Hydroxyprolines can be used as chiral building blocks in the synthesis of pharmaceuticals.

Technology Process of TRANS-4-HYDROXY-D-PROLINE HYDROCHLORIDE

There total 2 articles about TRANS-4-HYDROXY-D-PROLINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

(2R,4S)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate (135042-17-0) → (2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid hydrochloride (142347-81-7,441067-49-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

DOI:10.1021/ja3109664

Reference yield:

→ (2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid hydrochloride (142347-81-7,441067-49-8)

Guidance literature:

Reference yield: 45.0%

(2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid hydrochloride (142347-81-7,441067-49-8) + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → N-Fmoc 4-hydroxypropline (139262-20-7)

Guidance literature:

With sodium hydrogencarbonate; In 1,4-dioxane; water; at 0 - 20 ℃;

DOI:10.1021/ja3109664

upstream raw materials:

(2R,4S)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate

Downstream raw materials:

N-Fmoc 4-hydroxypropline

(7R,8aR)-7-[(5-cyclopropylpyrazin-2-yl)oxy]-2-{[3-(trifluoromethyl)phenyl]-sulfonyl}octahydropyrrolo[1,2-a]pyrazine

(7S,8aR)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydropyrrolo[1,2-a]-pyrazin-7-ol

(7S,8aR)-2-benzyl-7-hydroxyhexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Refernces

• 1、 -. "Benzamide derivatives". . . Retrieved 2008/06/13.