4-AMINO-2-METHYLTHIO-5-THIAZOLECARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 4-AMINO-2-METHYLTHIO-5-THIAZOLECARBOXYLIC ACID METHYL ESTER
• CAS No.: 60093-05-2
• Molecular Formula: C6H8N2O2S2
• Molecular Weight: 204.274
• Hs Code.: 2934100090
• Mol file: 60093-05-2.mol

Synonyms:4-Amino-2-(methylsulfanyl)thiazole-5-carboxylicacid methyl ester;4-Amino-2-(methylthio)-1,3-thiazole-5-carboxylic acid methylester;4-Amino-2-(methylthio)thiazole-5-carboxylic acid methyl ester;4-Amino-5-methoxycarbonyl-2-methylmercaptothiazole;Methyl4-amino-2-(methylsulfanyl)-thiazole-5-carboxylate;Methyl4-amino-2-(methylthio)-1,3-thiazole-5-carboxylate;Thiazole-5-carboxylic acid, 4-amino-2-methylthio-, methyl ester;methyl ester;

Chemical Property of 4-AMINO-2-METHYLTHIO-5-THIAZOLECARBOXYLIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 2.36E-05mmHg at 25°C
• Melting Point: 103.5 °C
• Refractive Index: 1.619
• Boiling Point: 359.5 °C at 760 mmHg
• PKA: 0.99±0.10(Predicted)
• Flash Point: 171.2 °C
• PSA: 118.75000
• Density: 1.43 g/cm³
• LogP: 1.81500
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-Amino-2-methylthio-thiazole-5-carboxylicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-AMINO-2-METHYLTHIO-5-THIAZOLECARBOXYLIC ACID METHYL ESTER

There total 4 articles about 4-AMINO-2-METHYLTHIO-5-THIAZOLECARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

potassium methyl cyanoiminodithiocarbonate (10191-61-4) + methyl chloroacetate (96-34-4) → thiazole-5-carboxylic acid, 4-amino-2-methylthio-, methylester (60093-05-2)

Guidance literature:

With triethylamine; In acetone;

DOI:10.1016/j.tetlet.2006.05.039

Reference yield:

4-((E)-2-Cyano-vinylamino)-2-methylsulfanyl-thiazole-5-carboxylic acid methyl ester (905434-97-1) → thiazole-5-carboxylic acid, 4-amino-2-methylthio-, methylester (60093-05-2)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2006.05.039

Reference yield:

4-(dimethylamino-methyleneamino)-2-methylsulfanyl-thiazole-5-carboxylic acid methyl ester → thiazole-5-carboxylic acid, 4-amino-2-methylthio-, methylester (60093-05-2)

Guidance literature:

Multi-step reaction with 2 steps

1: LiHMDS / acetonitrile; tetrahydrofuran

2: Et₃N / dimethylformamide

With triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.tetlet.2006.05.039

upstream raw materials:

potassium S-methyl N-cyanocarbamodithioate

methyl chloroacetate

4-((E)-2-Cyano-vinylamino)-2-methylsulfanyl-thiazole-5-carboxylic acid methyl ester

potassium methyl cyanoiminodithiocarbonate

Downstream raw materials:

methyl 4-amino-1,3-thiazole-5-carboxylatte

methylthiol

4-amino-2-methanesulfonylthiazole-5-carboxylic acid methyl ester

4-amino-2-(4-chloro-phenyl)-thiazole-5-carboxylic acid methyl ester

Refernces