1,1,2,3,3,3-Hexafluoropropyl ethyl ether

Base Information

• Chemical Name: 1,1,2,3,3,3-Hexafluoropropyl ethyl ether
• CAS No.: 380-34-7
• Molecular Formula: C5H6F6O
• Molecular Weight: 196.092
• Hs Code.: 2909199090
• European Community (EC) Number: 808-061-2
• DSSTox Substance ID: DTXSID20695972
• Nikkaji Number: J1.780.056F
• Mol file: 380-34-7.mol

Synonyms:380-34-7;1,1,2,3,3,3-Hexafluoropropyl ethyl ether;1-ethoxy-1,1,2,3,3,3-hexafluoropropane;1,1,2,3,3,3-Hexafluoropropylethylether;Ethyl 1,1,2,3,3,3-Hexafluoropropyl Ether;1,1,1,2,3,3-HEXAFLUOROPROPYL ETHYL ETHER;Ethyl 1,1,2,3,3,3-hexafluoropropyl ether;Ethyl 2H-perfluoropropyl ether;SCHEMBL1260725;DTXSID20695972;DMECHFLLAQSVAD-UHFFFAOYSA-N;MFCD00236122;AKOS006228193;E1020;FT-0605972;D90584

Chemical Property of 1,1,2,3,3,3-Hexafluoropropyl ethyl ether

Chemical Property:

• Vapor Pressure: 288mmHg at 25°C
• Refractive Index: 1.305
• Boiling Point: 288 mmHg at 25°C
• PSA: 9.23000
• Density: 1.302 g/cm³
• LogP: 2.51610
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 3
• Exact Mass: 196.03228378
• Heavy Atom Count: 12
• Complexity: 141

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,1,2,3,3,3-HexafluoropropylEthylEther ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 11-36/37/38
• Safety Statements: 16-26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(C(C(F)(F)F)F)(F)F

Technology Process of 1,1,2,3,3,3-Hexafluoropropyl ethyl ether

There total 6 articles about 1,1,2,3,3,3-Hexafluoropropyl ethyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

perfluoropropylene (116-15-4,13429-24-8,25120-07-4,6792-31-0) + ethanol (64-17-5) → 1,1,2,3,3,3-hexafluoropropyl ethyl ether (380-34-7)

Guidance literature:

With potassium hydroxide; at 20 - 40 ℃;

DOI:10.1023/B:RJAC.0000024585.14553.5f

Reference yield:

perfluoropropylene (116-15-4,13429-24-8,25120-07-4,6792-31-0) + sodium ethanolate (141-52-6) → 1,1,2,3,3,3-hexafluoropropyl ethyl ether (380-34-7)

Guidance literature:

In methanol; 1.) 3 h, 2.) room temperature;

DOI:10.1246/cl.1981.107

Reference yield:

perfluoropropylene (116-15-4,13429-24-8,25120-07-4,6792-31-0) + ethanol (64-17-5) → 1,1,2,3,3,3-hexafluoropropyl ethyl ether (380-34-7) + 2,3,3,3-tetrafluoropropionic acid ethyl ester (399-92-8)

Guidance literature:

With potassium hydroxide;

DOI:10.1021/ja01589a053

upstream raw materials:

perfluoropropylene

ethanol

sodium ethanolate

1,1,1,2,2,3,3-heptafluoro-3-iodo-propane

Downstream raw materials:

2,3,3,3-tetrafluoropropionic acid ethyl ester

diethyl 2-methyl-2-fluoromalonate

fluoromalonic acid diethyl ester

Refernces

• 1、 Park et al.. "-". . p. 1685. Retrieved 1956.
• 2、 Harsanyi, Antal,Sandford, Graham. "Fluorine gas for life science syntheses: Green metrics to assess selective direct fluorination for the synthesis of 2-fluoromalonate esters". supporting information. p. 3000 - 3009. Retrieved 2015/05/27.