2-HYDROXY-5-METHOXY-3-NITRO-BENZALDEHYDE

Base Information

• Chemical Name: 2-HYDROXY-5-METHOXY-3-NITRO-BENZALDEHYDE
• CAS No.: 34549-69-4
• Molecular Formula: C8H7 N O5
• Molecular Weight: 197.147
• Hs Code.: 2913000090
• Mol file: 34549-69-4.mol

Synonyms:m-Anisaldehyde,6-hydroxy-5-nitro- (6CI,7CI); 2-Hydroxy-5-methoxy-3-nitrobenzaldehyde;3-Nitro-5-methoxysalicylaldehyde; 5-Methoxy-3-nitro-2-hydroxybenzaldehyde;5-Methoxy-3-nitrosalicylaldehyde

Chemical Property of 2-HYDROXY-5-METHOXY-3-NITRO-BENZALDEHYDE

Chemical Property:

• Vapor Pressure: 0.00053mmHg at 25°C
• Melting Point: 129-134°C
• Boiling Point: 303.1°C at 760 mmHg
• PKA: 5.28±0.38(Predicted)
• Flash Point: 137.1°C
• PSA: 92.35000
• Density: 1.456g/cm³
• LogP: 1.64470

Purity/Quality:

99% ^*data from raw suppliers

2-Hydroxy-5-methoxy-3-nitrobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25-43
• Safety Statements: 36/37-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Hydroxy-5-methoxy-3-nitrobenzaldehyde is used in preparation of pyrimidine derivatives as VEGF receptor tyrosine kinase inhibitors useful in the treatment of cancer.

Technology Process of 2-HYDROXY-5-METHOXY-3-NITRO-BENZALDEHYDE

There total 4 articles about 2-HYDROXY-5-METHOXY-3-NITRO-BENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-hydroxy-5-methoxybenzaldehyde (672-13-9) → 3-nitro-5-methoxysalicylaldehyde (34549-69-4)

Guidance literature:

With nitric acid; In acetic acid; for 0.75h;

DOI:10.1039/P19900000047

Reference yield:

2-hydroxy-5-methoxybenzaldehyde (672-13-9) + nitric acid (7697-37-2,78989-43-2) + acetic acid (64-19-7,77671-22-8) → 3-nitro-5-methoxysalicylaldehyde (34549-69-4)

Guidance literature:

at 10 - 20 ℃;

Reference yield:

2,5-dimethoxy-3-nitrobenzaldehyde (74422-90-5) → 3-nitro-5-methoxysalicylaldehyde (34549-69-4)

Guidance literature:

upstream raw materials:

2-hydroxy-5-methoxybenzaldehyde

nitric acid

acetic acid

2,5-dimethoxy-3-nitrobenzaldehyde

Refernces

• 1、 Zaitsu, Kei,Katagi, Munehiro,Kamata, Hiroe,Kamata, Tooru,Shima, Noriaki,Miki, Akihiro,Iwamura, Tatsunori,Tsuchihashi, Hitoshi. "Discrimination and identification of the six aromatic positional isomers of trimethoxyamphetamine (TMA) by gas chromatography-mass spectrometry (GC-MS)". . p. 528 - 534. Retrieved 2008/09/20.
• 2、 Grenier, Jean-Luc,Catteau, Jean-Pierre,Cotelle, Philippe. "Nitration of electron-rich aromatic compounds by cerium ammonium nitrate coated on silica". . p. 1201 - 1208. Retrieved 2007/10/03.