4-hydroxy-3,5-dimethoxyphenethyl alcohol

Base Information

• Chemical Name: 4-hydroxy-3,5-dimethoxyphenethyl alcohol
• CAS No.: 20824-45-7
• Molecular Formula: C₁₀H₁₄O₄
• Molecular Weight: 198.219
• Mol file: 20824-45-7.mol

Synonyms:4-hydroxy-3,5-dimethoxyphenethyl alcohol

Chemical Property of 4-hydroxy-3,5-dimethoxyphenethyl alcohol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-hydroxy-3,5-dimethoxyphenethyl alcohol

There total 12 articles about 4-hydroxy-3,5-dimethoxyphenethyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

sodium methylate (124-41-4) + 2,6-dibromo-4-(2-hydroxy-ethyl)-phenol → 4-hydroxy-3,5-dimethoxyphenethyl alcohol (20824-45-7)

Guidance literature:

sodium methylate; With copper(I) bromide; In methanol; at 20 ℃;

2,6-dibromo-4-(2-hydroxy-ethyl)-phenol; In methanol; at 90 ℃; for 3h;

With sodium hydroxide; In tetrahydrofuran;

DOI:10.1007/s00044-012-0052-8

Reference yield: 92.0%

2-(4-hydroxy-3,5-dimethoxyphenyl)acetic acid (4385-56-2) → 4-hydroxy-3,5-dimethoxyphenethyl alcohol (20824-45-7)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 20 ℃; Cooling with ice;

DOI:10.1016/j.carres.2009.11.020

Reference yield: 41.0%

sodium methylate (124-41-4) + carbonic acid dimethyl ester (616-38-6) + 2,6-dibromo-4-(2-hydroxy-ethyl)-phenol → 4-hydroxy-3,5-dimethoxyphenethyl methyl carbonate (1375102-20-7) + 4-hydroxy-3,5-dimethoxyphenethyl alcohol (20824-45-7)

Guidance literature:

sodium methylate; carbonic acid dimethyl ester; With copper(I) bromide; In methanol; at 20 ℃; Green chemistry;

2,6-dibromo-4-(2-hydroxy-ethyl)-phenol; In methanol; at 90 ℃; for 3h; Green chemistry;

DOI:10.1007/s00044-012-0052-8

upstream raw materials:

2-(4-hydroxy-3,5-dimethoxyphenyl)acetic acid

sodium methylate

syringylglyoxalic acid

carbonic acid dimethyl ester

Downstream raw materials:

3,4,5-trihydroxyphenethyl methyl carbonate

3,4,5-trihydroxyphenethyl alcohol

4-hydroxy-3,5-dimethoxyphenethyl ethanoate

4,5,6,7-tetramethoxybenzofuran

Refernces

• 1、 Hu, Zhenhua,Li, Suxiang,Lu, Fachuang,Shi, Lanlan,Wang, Chen,Yue, Fengxia,Zhang, Han,Zhao, Chengke. "Profiling of the formation of lignin-derived monomers and dimers from: Eucalyptus alkali lignin". supporting information. p. 7366 - 7375. Retrieved 2020/11/18.
• 2、 Yang, Fei,Lian, Gaoyan,Yu, Biao. "Synthesis of raphanuside, an unusual oxathiane-fused thioglucoside isolated from the seeds of Raphanus sativus L.". experimental part. p. 309 - 314. Retrieved 2010/03/26.