5,7-Dibromo-2,3-dihydrobenzofuran

Base Information

• Chemical Name: 5,7-Dibromo-2,3-dihydrobenzofuran
• CAS No.: 123266-59-1
• Molecular Formula: C8H6Br2O
• Molecular Weight: 277.94
• Hs Code.: 2932999099
• DSSTox Substance ID: DTXSID40381284
• Wikidata: Q82172014
• Mol file: 123266-59-1.mol

Synonyms:5,7-Dibromo-2,3-dihydrobenzofuran;123266-59-1;5,7-dibromo-2,3-dihydro-1-benzofuran;5,7-dibromo-2,3-dihydro-benzofuran;5,7-Dibromo-2,3-dihydrobenzo[b]furan;5,7-Dibromocoumaran;Benzofuran,5,7-dibromo-2,3-dihydro-;Benzofuran, 5,7-dibromo-2,3-dihydro-;SCHEMBL153211;DTXSID40381284;NJQJUJHJJZMVNB-UHFFFAOYSA-N;MFCD00191427;AKOS015912355;5,7-dibromo-2,3-dihydro-1-benzo[b]furan;AM20020318;D2336;FT-0713746;A805038;J-004905;[(5-methyl-1,3,4-thiadiazol-2-yl)amino](oxo)aceticacid

Chemical Property of 5,7-Dibromo-2,3-dihydrobenzofuran

Chemical Property:

• Vapor Pressure: 0.00135mmHg at 25°C
• Melting Point: 34-36 °C
• Refractive Index: 1.634
• Boiling Point: 307.1 °C at 760 mmHg
• Flash Point: 123.6 °C
• PSA: 9.23000
• Density: 1.958 g/cm³
• LogP: 3.14650
• Storage Temp.: 2-8°C
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 277.87649
• Heavy Atom Count: 11
• Complexity: 151

Purity/Quality:

98%,99%, ^*data from raw suppliers

5,7-Dibromo-2,3-dihydrobenzofuran ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC2=C1C=C(C=C2Br)Br

Technology Process of 5,7-Dibromo-2,3-dihydrobenzofuran

There total 2 articles about 5,7-Dibromo-2,3-dihydrobenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2.3-dihydrobenzofuran (496-16-2) → 5,7-Dibromo-2,3-dihydrobenzofuran (123266-59-1)

Guidance literature:

With bromine; sodium thiosulfate; In dichloromethane; acetic acid;

Reference yield:

2.3-dihydrobenzofuran (496-16-2) + sodium thiosulfate → 5,7-Dibromo-2,3-dihydrobenzofuran (123266-59-1)

Guidance literature:

With bromine; In dichloromethane; acetic acid;

Reference yield: 22.0%

5,7-Dibromo-2,3-dihydrobenzofuran (123266-59-1) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 5-bromo-2,3-dihydrobenzo[b]furan-7-carboaldehyde (281678-73-7)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 - 20 ℃;

upstream raw materials:

2.3-dihydrobenzofuran

Downstream raw materials:

5-bromo-2,3-dihydrobenzo[b]furan-7-carboxylic acid

5-bromo-7-carboxy-2,3-dihydrobenzofuran chloride

5-iodo-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2,3-dihydrobenzofurancarboxamide

5-bromo-2,3-dihydrobenzo[b]furan-7-carboaldehyde

Refernces

• 1、 Hou, Jieping,Li, Zejiang,Jia, Xiao-Dong,Liu, Zhong-Quan. "Bromination of arenes using I2O5-KBr in water". supporting information. p. 181 - 187. Retrieved 2013/12/04.
• 2、 -. "PHAMACEUTICAL PREPARATIONS COMPRISING INSULIN". Page/Page column 176. . Retrieved 2010/02/15.