2-Methoxy-3-methylpyridine

Base Information

• Chemical Name: 2-Methoxy-3-methylpyridine
• CAS No.: 19230-59-2
• Molecular Formula: C7H9NO
• Molecular Weight: 123.155
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID40517864
• Wikidata: Q82380104
• Mol file: 19230-59-2.mol

Synonyms:2-Methoxy-3-methylpyridine;19230-59-2;2-Methoxy-3-picoline;Pyridine, 2-methoxy-3-methyl-;methylmethoxypyridine;SCHEMBL129117;DTXSID40517864;DVGNYVVFWIWKON-UHFFFAOYSA-N;MFCD07367922;AKOS006286290;PYRIDINE,2-METHOXY-3-METHYL-;AB31414;DS-5076;AC-14266;CS-0153433;FT-0653180;C73664

Chemical Property of 2-Methoxy-3-methylpyridine

Chemical Property:

• Vapor Pressure: 2.47mmHg at 25°C
• Refractive Index: 1.494
• Boiling Point: 165.4 °C at 760 mmHg
• PKA: 3.69±0.10(Predicted)
• Flash Point: 57.7 °C
• PSA: 22.12000
• Density: 1.001 g/cm³
• LogP: 1.39860
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 123.068413911
• Heavy Atom Count: 9
• Complexity: 85

Purity/Quality:

98%min ^*data from raw suppliers

2-Methoxy-3-methylpyridine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(N=CC=C1)OC

Technology Process of 2-Methoxy-3-methylpyridine

There total 9 articles about 2-Methoxy-3-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

2-fluoro-3-methylpyridine (2369-18-8) + sodium methylate (124-41-4) → 2-methoxy-3-methylpyridine (19230-59-2)

Guidance literature:

In methanol; for 0.25h; Heating / reflux;

Reference yield: 43.0%

2-methoxy-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine (532391-31-4) + methyl iodide (74-88-4) → 2-methoxy-3-methylpyridine (19230-59-2)

Guidance literature:

With C₂₁H₃₀ClNPPd; potassium tert-butylate; In tert-Amyl alcohol; at 65 ℃; for 18h; Sealed tube; Inert atmosphere; Glovebox;

DOI:10.1021/acs.orglett.9b00025

Reference yield:

2-methoxypyridine (1628-89-3) → 4-bromo-2-methoxypyridine (100367-39-3) + 3-Bromo-2-methoxypyridine (13472-59-8) + 2-methoxy-3-methylpyridine (19230-59-2)

Guidance literature:

With 4-(4-(dihexadecylamino)styryl)-N-methylpyridinium iodide; methyllithium; bromine; Yield given. Multistep reaction. Title compound not separated from byproducts; 1.) Et₂O, THF, 0 deg C, 3 h, 2.) Et₂O, THF, -60 deg C, 0.5 h;

DOI:10.1021/jo00242a005

upstream raw materials:

2-methoxypyridine

allyl bromide

methyl iodide

3-Methylpyridine

Downstream raw materials:

6-methoxy-5-methylpyridin-3-amine

2-methoxy-3-methyl-5-nitropyridine

Refernces

• 1、 -. "IMIDAZOPYRIDINE COMPOUND". Page/Page column 61-62. . Retrieved 2010/02/14.
• 2、 Stavber, Stojan,Zupan, Marko. "Reactions of Caesium Fluoroxysulphate with Pyridine". . p. 775 - 776. Retrieved 2007/10/02.