5-Bromo-3-chloro-2-fluoropyridine

Base Information

• Chemical Name: 5-Bromo-3-chloro-2-fluoropyridine
• CAS No.: 38185-56-7
• Molecular Formula: C5H2BrClFN
• Molecular Weight: 210.433
• Hs Code.: 2933399090
• European Community (EC) Number: 806-987-1
• DSSTox Substance ID: DTXSID70476612
• Wikidata: Q72452669
• Mol file: 38185-56-7.mol

Synonyms:5-Bromo-3-chloro-2-fluoropyridine;38185-56-7;MFCD09834365;2-FLUORO-3-CHLORO-5-BROMOPYRIDINE;CYCLOHEXYL-PHENYLACETATE;SCHEMBL1742074;DTXSID70476612;WXKLHBHJIBAXQH-UHFFFAOYSA-N;AKOS015834463;AB52757;AC-5075;AM62395;CS-W003656;GS-5808;BP-11820;SY017801;FT-0657320;5-Bromo-3-chloro-2-fluoropyridine, AldrichCPR;A22992;EN300-199516

Chemical Property of 5-Bromo-3-chloro-2-fluoropyridine

Chemical Property:

• Appearance/Colour: White powder
• Vapor Pressure: 0.342mmHg at 25°C
• Melting Point: 60℃
• Refractive Index: 1.555
• Boiling Point: 206.3 °C at 760 mmHg
• PKA: -5.07±0.20(Predicted)
• Flash Point: 78.6 °C
• PSA: 12.89000
• Density: 1.83 g/cm³
• LogP: 2.63660
• Storage Temp.: Refrigerated.
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 208.90432
• Heavy Atom Count: 9
• Complexity: 103

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Bromo-3-chloro-2-fluoropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

Useful:

• Canonical SMILES: C1=C(C=NC(=C1Cl)F)Br

Technology Process of 5-Bromo-3-chloro-2-fluoropyridine

There total 2 articles about 5-Bromo-3-chloro-2-fluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

5-bromo-3-chloropyridin-2-ylamine (38185-55-6) → 5-bromo-3-chloro-2-fluoropyridine (38185-56-7)

Guidance literature:

With pyridine; hydrogen fluoride; sodium nitrite; at 20 ℃; Cooling with ice;

Reference yield:

→ 5-bromo-3-chloro-2-fluoropyridine (38185-56-7)

Guidance literature:

Aus 2-Amino-5-brom-3-chlorpyridin IV;

Reference yield: 97.0%

5-bromo-3-chloro-2-fluoropyridine (38185-56-7) + phenylmethanethiol (100-53-8) → 5-(benzylthio)-3-chloro-2-fluoropyridine

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; for 3h; Time; Inert atmosphere; Reflux;

upstream raw materials:

5-bromo-3-chloropyridin-2-ylamine

Downstream raw materials:

3-chloro-2-fluoro-5-(4-methylphenyl)thiopyridine

3-chloro-2-fluoro-5-(4-chlorophenyl)thiopyridine

3-chloro-2-fluoro-5-(3-methylphenyl)thiopyridine

3-chloro-2-fluoro-5-(3-chlorophenyl)thiopyridine

Refernces

• 1、 -. "FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE". Page/Page column 143-144. . Retrieved 2010/08/08.