38185-55-6

Basic information

• Product Name: 2-AMINO-3-CHLORO-5-BROMOPYRIDINE
• Synonyms: 2-AMINO-3-CHLORO-5-BROMOPYRIDINE;5-bromo-3-chloropyridin-2-amine;2-amino-5-bromo-3-chloropyridine;2-Pyridinamine,5-bromo-3-chloro-;5-BroMo-3-chloro-pyridin-2-ylaMine;2-AMino-5-broMo-3-chloroyridine;5-Bromo-3-chloro-2-pyridinamine
• CAS NO: 38185-55-6
• Molecular Formula: C₅H₄BrClN₂
• Molecular Weight: 207.46
• Product Categories: amine|alkyl bromide|alkyl chloride
• Mol File: 38185-55-6.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 232.551 °C at 760 mmHg
• Flash Point: 94.444 °C
• Appearance: /
• Density: 1.835 g/cm³
• Vapor Pressure: 0.059mmHg at 25°C
• Refractive Index: 1.648
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-AMINO-3-CHLORO-5-BROMOPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-3-CHLORO-5-BROMOPYRIDINE(38185-55-6)
• EPA Substance Registry System: 2-AMINO-3-CHLORO-5-BROMOPYRIDINE(38185-55-6)

Safety Data

• Hazardous Substances Data: 38185-55-6(Hazardous Substances Data)

Usage

General Description

2-Amino-3-chloro-5-bromopyridine is a chemical compound consisting of a pyridine ring with an amino group at the 2-position, a chlorine atom at the 3-position, and a bromine atom at the 5-position. 2-AMINO-3-CHLORO-5-BROMOPYRIDINE is commonly used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and organic materials. It is also used as a building block in the production of heterocyclic compounds and complex organic molecules. Additionally, 2-amino-3-chloro-5-bromopyridine has potential applications in the field of medicinal chemistry and drug development. Due to its specific structure and reactivity, it has garnered significant interest in the scientific research community for its potential use in the synthesis of bioactive compounds.

InChI:InChI=1/C5H4BrClN2/c6-3-1-4(7)5(8)9-2-3/h1-2H,(H2,8,9)

Upstream product

• 504-29-0 2-aminopyridine 
• 39620-04-7 2-amino-3-chloropyridine 
• 1072-97-5 5-bromo-2-pyridylamine 
• 128-09-6 N-chloro-succinimide 

Downstream Products

• 1032758-99-8 3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine 
• 79456-26-1 2-amino-3-chloro-5-(trifluoromethyl)pyridine 
• 38185-56-7 5-bromo-3-chloro-2-fluoropyridine 
• 588729-98-0 N-(6-phenyl-thiazolo[4,5-b]pyridin-2-yl)-benzamide 
• 588729-97-9 N-(6-bromo[1,3]thiazolo[4,5-b]pyridin-2-yl)benzamide 
• 588729-96-8 N-benzoyl-N'-(5-bromo-3-chloro-2-pyridyl)thiourea 
• 156361-02-3 2-amino-3-chloro-5-cyanopyridine 

Relevant articles and documents

Method for synthesizing 2-amino-3-chloro-5-trifluoromethylpyridine

The invention discloses a method for synthesizing 2-amino-3-chloro-5-trifluoromethylpyridine, and belongs to the technical field of organic synthesis. Specifically, starting from 2-aminopyridine, three chemical reactions of bromination, chlorination and coupling are involved, and two organic solvents are used in the whole process; and after the three-step reaction, recrystallization treatment is carried out to obtain the high-purity 2-amino-3-chloro-5-trifluoromethylpyridine. The method is mild in reaction condition and easy to control, and the obtained product is high in purity; reaction rawmaterials and organic solvents are easy to obtain and low in price, and a new way is provided for large-scale production.

DIARYLTHIOHYDANTOIN COMPOUND AS ANDROGEN RECEPTOR ANTAGONIST

The present application belongs to the field of medicine. In particular, the present application relates to a diarylthiohydantoin compound as an androgen receptor antagonist or a pharmaceutically acceptable salt thereof, a preparation method of the same, a pharmaceutical composition comprising the compound, and a use thereof in treating a cell proliferative disease mediated by androgen. The compound of the present application has good antagonistic effect on androgen receptor and exhibits excellent antitumor effect.

Design, synthesis, and biological evaluation of novel imidazo[1,2-a]pyridine derivatives as potent c-met inhibitors

A series of imidazo[1,2-a]pyridine derivatives against c-Met was designed by means of bioisosteric replacement. In this study, a selective, potent c-Met inhibitor, 22e was identified, with IC50 values of 3.9 nM against c-Met kinase and 45.0 nM