3-Chloro-2-fluoro-5-hydroxypyridine

Base Information

• Chemical Name: 3-Chloro-2-fluoro-5-hydroxypyridine
• CAS No.: 209328-72-3
• Molecular Formula: C₅H₃ClFNO
• Molecular Weight: 147.536
• Hs Code.: 2933399090
• Mol file: 209328-72-3.mol

Synonyms:3-Chloro-2-fluoro-5-hydroxypyridine;

Chemical Property of 3-Chloro-2-fluoro-5-hydroxypyridine

Chemical Property:

• Vapor Pressure: 1.65E-05mmHg at 25°C
• Refractive Index: 1.552
• Boiling Point: 354.4 °C at 760 mmHg
• PKA: 8.25±0.10(Predicted)
• Flash Point: 168.1 °C
• PSA: 33.12000
• Density: 1.517 g/cm³
• LogP: 1.57970
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

3-Chloro-2-fluoro-5-hydroxypyridine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Chloro-2-fluoro-5-hydroxypyridine

There total 2 articles about 3-Chloro-2-fluoro-5-hydroxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

5-bromo-3-chloro-2-fluoropyridine (38185-56-7) → 5-chloro-6-fluoropyridin-3-ol (209328-72-3)

Guidance literature:

5-bromo-3-chloro-2-fluoropyridine; With n-butyllithium; In diethyl ether; at -78 ℃; for 0.25h;

With Triisopropyl borate; In diethyl ether; at 20 ℃;

With dihydrogen peroxide; sodium hydroxide; In diethyl ether; water; at 20 ℃; for 0.5h;

Reference yield:

→ 5-chloro-6-fluoropyridin-3-ol (209328-72-3)

Guidance literature:

Reference yield: 54.0%

5-chloro-6-fluoropyridin-3-ol (209328-72-3) + methyl 2,4,5-trifluorobenzoate (20372-66-1) → tert-butyl 4-[(5-chloro-6-fluoropyridin-3-yl)oxy]-2,5-difluorobenzoate (1446444-63-8)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 18h;

upstream raw materials:

5-bromo-3-chloro-2-fluoropyridine

Downstream raw materials:

tert-butyl 4-[(5-chloro-6-fluoropyridin-3-yl)oxy]-2,5-difluorobenzoate

4-[(5-chloro-6-fluoropyridin-3-yl)oxy]-2,5-difluoro-N-[(dimethylamino)sulfonyl]benzamide

4-{[5-chloro-6-(3-fluoropyrrolidin-1-yl)pyridine-3-yl]oxy}-N-[(dimethylamino)sulfonyl]-2,5-difluorobenzamide formate salt

4-((5-chloro-6-((1,1,1-trifluoropropan-2-yl)oxy)pyridin-3-yl)oxy)-N-[(dimethylamino)sulfonyl]-2,5-difluorobenzamide

Refernces

• 1、 -. "3-Pyridyl enantiomers and their use as analgesics". . . Retrieved 2008/06/13.