5-AMINO-2-IODOBENZOTRIFLUORIDE

Base Information

• Chemical Name: 5-AMINO-2-IODOBENZOTRIFLUORIDE
• CAS No.: 155403-06-8
• Molecular Formula: C₇H₅F₃IN
• Molecular Weight: 287.023
• Hs Code.: 2921420090
• Mol file: 155403-06-8.mol

Synonyms:5-AMINO-2-IODOBENZOTRIFLUORIDE;4-Iodo-3-(trifluoromethyl)aniline;5-Amino-2-iodobenzotrifluoride 98%;5-Amino-2-iodobenzotrifluoride98%

Chemical Property of 5-AMINO-2-IODOBENZOTRIFLUORIDE

Chemical Property:

• Boiling Point: 268.2°Cat760mmHg
• Flash Point: 116°C
• PSA: 26.02000
• Density: 1.948g/cm³
• LogP: 3.47340
• Sensitive.: Light Sensitive
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98%min ^*data from raw suppliers

5-Amino-2-iodobenzotrifluoride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: It is an important organic intermediate used in agrochemicals, pharmaceuticals and dyestuff fields and it is also an intermediate in organic syntheses.

Technology Process of 5-AMINO-2-IODOBENZOTRIFLUORIDE

There total 1 articles about 5-AMINO-2-IODOBENZOTRIFLUORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-iodo-4-nitro-2-(trifluoromethyl)benzene (400-75-9) → 3-(trifluoromethyl)-4-iodobenzenamine (155403-06-8)

Guidance literature:

In methanol; aluminum nickel;

Reference yield: 91.0%

zinc(II) cyanide (557-21-1) + 3-(trifluoromethyl)-4-iodobenzenamine (155403-06-8) → 4-amino-2-trifluoromethylbenzonitrile (654-70-6)

Guidance literature:

With C₁₂H₁₀N^(1-)*CH₃O₃S^(1-)*Pd⁽²⁺⁾*C₃₉H₃₂OP₂; In tetrahydrofuran; water; at 65 ℃; for 16h; Micellar solution;

DOI:10.1002/cctc.202001742

Reference yield: 76.0%

3-(trifluoromethyl)-4-iodobenzenamine (155403-06-8) + carbon dioxide (124-38-9,18923-20-1) → 4-amino-2-trifluoromethylbenzonitrile (654-70-6)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; copper(I) oxide; phenylsilane; ammonia; at 180 ℃; for 20h; under 2280.15 Torr; chemoselective reaction; Sealed tube;

DOI:10.1016/j.chempr.2018.09.009

upstream raw materials:

1-iodo-4-nitro-2-(trifluoromethyl)benzene

Downstream raw materials:

4-amino-2-trifluoromethylbenzonitrile

Refernces

• 1、 -. "Isoquinoline derivatives with angiogenesis inhibiting activity". . . Retrieved 2008/06/13.