N-(2-hydroxy-1-phenylethyl)acetamide

Base Information

• Chemical Name: N-(2-hydroxy-1-phenylethyl)acetamide
• CAS No.: 24666-05-5
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.219
• European Community (EC) Number: 818-894-3
• Mol file: 24666-05-5.mol

Synonyms:N-(2-hydroxy-1-phenylethyl)acetamide;24666-05-5;D(-)-Ac-alpha-phenylglycinol;SCHEMBL607610;AKOS012486882;SB44893;G29617;EN300-1662356;Z1097082934

Chemical Property of N-(2-hydroxy-1-phenylethyl)acetamide

Chemical Property:

• XLogP3: 0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 179.094628657
• Heavy Atom Count: 13
• Complexity: 164

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(=O)NC(CO)C1=CC=CC=C1

Technology Process of N-(2-hydroxy-1-phenylethyl)acetamide

There total 10 articles about N-(2-hydroxy-1-phenylethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-acetoxy-1-phenylethylamine hydrobromide (133649-07-7) → 2-(N-acetylamino)-2-phenylethanol (24666-05-5)

Guidance literature:

With sodium hydroxide; In dichloromethane;

DOI:10.1021/jo00009a027

Reference yield: 81.0%

C16H27NO2Si → 2-(N-acetylamino)-2-phenylethanol (24666-05-5)

Guidance literature:

With Povidone-Iodine; In methanol; at 30 ℃; for 1h;

DOI:10.1016/j.tetlet.2019.05.059

Reference yield:

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + N-bromoacetamide (79-15-2) → 2-(N-acetylamino)-2-phenylethanol (24666-05-5) + (S)-N-(2-hydroxy-2-phenylethyl)acetamide + (R)-N-(2-hydroxy-2-phenylethyl)acetamide (149342-37-0)

Guidance literature:

With lithium hydroxide; Hydroquinone 1,4-phthalazinediyl diether; Amberlite XAD-16-OsO₄; In acetonitrile; at 4 ℃; for 4h; Title compound not separated from byproducts;

DOI:10.1039/b303022a

upstream raw materials:

N-(2-chloro-1-phenylethyl)acetamide

2-methyl-4-phenyl-4,5-dihydrooxazole

2-acetoxy-1-phenylethylamine hydrobromide

styrene

Downstream raw materials:

C₁₀H₁₁NS

Refernces

• 1、 Ke, Yanxiong,Lu, Guangying,Ren, Jiangmeng,Wang, Di,Zeng, Bu-Bing. "Catalytic removal of tert-butyldimethylsilyl (TBS) ether by PVP-I". . . Retrieved 2019/09/06.
• 2、 Jo, Cheon Hee,Han, Sien-Ho,Yang, Jung Woon,Roh, Eun Joo,Shin, Ueon-Sang,Song, Choong Eui. "Osmylated macroporous resins: Safe, highly efficient and recyclable catalysts for asymmetric aminohydroxylation of olefins". . p. 1312 - 1313. Retrieved 2007/10/03.