79-15-2 Usage
Description
N-BROMOACETAMIDE is a white powder that is used to abolish the rapid inactivation of membrane sodiumand potassium-ion channels. It also functions in the kinetics of cardiac sodium ion channels.
Uses
Used in Pharmaceutical Industry:
N-BROMOACETAMIDE is used as a chemical agent for abolishing the rapid inactivation of membrane sodiumand potassium-ion channels. This property makes it useful in the development of drugs targeting ion channels, which are involved in various physiological processes and diseases.
Used in Cardiology:
In the field of cardiology, N-BROMOACETAMIDE is used to study and modulate the kinetics of cardiac sodium ion channels. This can help in understanding the mechanisms of cardiac arrhythmias and developing potential therapeutic agents for their treatment.
Air & Water Reactions
Soluble in water.
Reactivity Profile
N-BROMOACETAMIDE is sensitive to light, moisture, and heat. . N-BROMOACETAMIDE decomposes rapidly at elevated temperatures, in the presence of moisture and light.
Fire Hazard
Flash point data are not available for N-BROMOACETAMIDE, but N-BROMOACETAMIDE is probably combustible.
Purification Methods
A possible contaminant is CH3CONBr2. Recrystallise it from CHCl3/hexane (1:1, seed if necessary) or water and dry over CaCl2. It is a brominating agent. [Oliveto & Gerold Org Synth Coll Vol IV 104 1963.] Alternatively, dissolve it in the minimum volume of warm H2O (60o), then cool in an ice bath, collect the crystals and dry them in an anhydrous atmosphere, dissolve in Et2O, chill and evaporate till crystallisation. Dry the crystals in vacuo at 25o, then at 45o (m 108o). Crystallise from CHCl3 (m 103o). Estimate the available Br iodometrically [Buckles et al. J Org Chem 23 483 1958]. [Beilstein 2 H 181, 2 I 82, 2 II 180, 2 III 406, 2 IV 417.]
Check Digit Verification of cas no
The CAS Registry Mumber 79-15-2 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 7 and 9 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 79-15:
(4*7)+(3*9)+(2*1)+(1*5)=62
62 % 10 = 2
So 79-15-2 is a valid CAS Registry Number.
InChI:InChI=1/C2H4BrNO/c1-2(5)4-3/h1H3,(H,4,5)
79-15-2Relevant articles and documents
One-pot synthesis of 2-oxazolines from ethyl α-cyanocinnamate derivatives with n-bromoacetamide
Chen, Zhanguo,Wen, Hua,Li, Wenli,Zhou, Jimei,Hu, Junli,Xia, Wei
, p. 794 - 802 (2014/06/10)
An efficient method for the one-pot synthesis of 2-oxazolines from ethyl α-cyanocinnamate derivatives with N-bromoacetamide in the presence of K3PO4 has been developed. The reaction performed smoothly and cleanly to give 2-oxazolines in good to excellent yields (up to 98%) within 4.5 h in acetone at room temperature without protection of inert gases. A total of 13 examples have been investigated. A possible nucleophilic addition reaction mechanism is proposed.
K3PO4-catalyzed regiospecific aminobromination of βnitrostyrene derivatives with N-Bromoacetamide as aminobtominating agent
Chen, Zhan-Guo,Wang, Yun,Wei, Jun-Fa,Zhao, Peng-Fei,Shi, Xian-Ying
experimental part, p. 2085 - 2088 (2010/06/16)
"Chemical Equation Presented" A very simple, efficient, and regiospecific protocol for aminobromination of a wide scope of β-nitrostyrene derivatives with N-bromoacetamide (NBA) as nitrogen/ bromine sources has been developed by using K3PO4 as catalyst. The reaction proceeded smoothly and cleanly to give the bromoamines in good to excellent yields (78-99%) within 24 h in CH2Cl2 at room temperature without protection of inert gases. A possible mechanism involving a nucleophilic conjugate addition was proposed.
Organic Synthesis Using Sodium Bromate. II. A Facile Synthesis of N-Bromo Imides and Amides Using Sodium Bromate and Hydrobromic Acid (or Sodium Bromide) in the Presence of Sulfuric Acid
Fujisaki, Shizuo,Hamura, Satoshi,Eguchi, Hisao,Nishida, Akiko
, p. 2426 - 2428 (2007/10/02)
The reaction of imides and amides in water (or aqueous acetic acid) with sodium bromate and hydrobromic acid (or sodium bromide) in the presence of sulfuric acid under mild conditions gave the corresponding N-bromides in high yields.