2-hydroxy-4-methoxybenzhydrol

Base Information

• Chemical Name: 2-hydroxy-4-methoxybenzhydrol
• CAS No.: 926236-29-5
• Molecular Formula: C₁₄H₁₄O₃
• Molecular Weight: 230.263
• Mol file: 926236-29-5.mol

Synonyms:2-hydroxy-4-methoxybenzhydrol

Chemical Property of 2-hydroxy-4-methoxybenzhydrol

Chemical Property:

Purity/Quality:

95+% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-hydroxy-4-methoxybenzhydrol

There total 4 articles about 2-hydroxy-4-methoxybenzhydrol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Hydroxy-4-methoxybenzaldehyde (673-22-3) + phenylmagnesium bromide (100-58-3) → 2-hydroxy-4-methoxybenzhydrol (926236-29-5)

Guidance literature:

In tetrahydrofuran; at -78 ℃; Inert atmosphere;

DOI:10.1021/ja309076g

Reference yield:

2-bromo-5-methoxyphenol (63604-94-4) + benzaldehyde (100-52-7) → 2-hydroxy-4-methoxybenzhydrol (926236-29-5)

Guidance literature:

2-bromo-5-methoxyphenol; benzaldehyde; With magnesium; In tetrahydrofuran; at 20 - 85 ℃; for 2h;

In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol302181z

Reference yield:

2-Hydroxy-4-methoxybenzaldehyde (673-22-3) → 2-hydroxy-4-methoxybenzhydrol (926236-29-5)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 6h; Inert atmosphere;

DOI:10.1021/acs.joc.9b03479

upstream raw materials:

2-bromo-5-methoxyphenol

benzaldehyde

2-Hydroxy-4-methoxybenzaldehyde

phenylmagnesium bromide

Downstream raw materials:

Benzophenone-3

C₁₆H₁₈O₃

(S,E)-2-(1,3-diphenylallyl)-5-methoxyphenol

(S,E)-2-(3-(4-fluorophenyl)-1-phenylallyl)-5-methoxyphenol

Refernces

• 1、 Chen, Lian-Mei,Zhao, Juan,Xia, An-Jie,Guo, Xiao-Qiang,Gan, Ya,Zhou, Chuang,Yang, Zai-Jun,Yang, Jun,Kang, Tai-Ran. "A base-promoted cascade reaction of α,β-unsaturated: N -tosylhydrazones with o -hydroxybenzyl alcohols: Highly regioselective synthesis of N-sec -alkylpyrazoles". supporting information. p. 8561 - 8570. Retrieved 2019/10/02.
• 2、 Wang, Yifeng,Zhang, Cheng,Wang, Haojiang,Jiang, Yidong,Du, Xiaohua,Xu, Danqian. "Bifunctional Amine-Squaramide Catalyzed Friedel–Crafts Alkylation Based on ortho-Quinone Methides in Oil-Water Phases: Enantioselective Synthesis of Triarylmethanes". supporting information. p. 791 - 797. Retrieved 2017/03/11.