N-[(2,4-dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine

Base Information

• Chemical Name: N-[(2,4-dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine
• CAS No.: 1063733-41-4
• Molecular Formula: C₁₁H₁₃N₃O₂S
• Molecular Weight: 251.309
• Hs Code.: 2922390090
• Mol file: 1063733-41-4.mol

Synonyms:N-[(2,4-dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine

Chemical Property of N-[(2,4-dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine

Chemical Property:

• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98% ^*data from raw suppliers

N-(2,4-Dimethoxybenzyl)-1,2,4-thiadiazol-5-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[(2,4-dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine

There total 5 articles about N-[(2,4-dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.1%

1,3,4-thiadiazol-5-amine (7552-07-0) + 2,4-Dimethoxybenzaldehyde (613-45-6) → N-[(2,4-dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine (1063733-41-4)

Guidance literature:

1,3,4-thiadiazol-5-amine; 2,4-Dimethoxybenzaldehyde; In toluene; for 2h; Reflux; Dean-Stark;

With sodium tetrahydroborate; In methanol; toluene; at 0 ℃; for 18h; Dean-Stark;

DOI:10.1016/j.bmcl.2017.04.040

Reference yield: 53.0%

(E)-N-(2,4-dimethoxybenzylidene)-1,2,4-thiadiazol-5-amine → N-[(2,4-dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine (1063733-41-4)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 16h;

DOI:10.1021/acsmedchemlett.5b00447

Reference yield:

C11H11N3O2S → N-[(2,4-dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine (1063733-41-4)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃;

upstream raw materials:

1,3,4-thiadiazol-5-amine

2,4-Dimethoxybenzaldehyde

sodium tris(acetoxy)borohydride

Downstream raw materials:

3-cyano-N-[(2,4-dimethoxyphenyl)methyl]-4-fluoro-N-(1,2,4-thiadiazol-5-yl)benzene-1-sulfonamide

3-cyano-N-(2,4-dimethoxybenzyl)-4-[(3-methoxyphenyl)thio]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide

3-cyano-N-(2,4-dimethoxybenzyl)-4-[2-methoxy-4-(trifluoromethyl)benzyl]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide

3-cyano-N-(2,4-dimethoxybenzyl)-4-[2-pyridazin-4-yl-4-(trifluoromethyl)benzyl]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide

Refernces

• 1、 DiMauro, Erin F.,Altmann, Stephen,Berry, Loren M.,Bregman, Howard,Chakka, Nagasree,Chu-Moyer, Margaret,Bojic, Elma Feric,Foti, Robert S.,Fremeau, Robert,Gao, Hua,Gunaydin, Hakan,Guzman-Perez, Angel,Hall, Brian E.,Huang, Hongbing,Jarosh, Michael,Kornecook, Thomas,Lee, Josie,Ligutti, Joseph,Liu, Dong,Moyer, Bryan D.,Ortuno, Daniel,Rose, Paul E.,Schenkel, Laurie B.,Taborn, Kristin,Wang, Jean,Wang, Yan,Yu, Violeta,Weiss, Matthew M.. "Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors". . p. 7818 - 7839. Retrieved 2016.
• 2、 -. "Sulfonamide compound used as sodium channel blocker, and application thereof". Paragraph 0076; 0078; 0083; 0084; 0234; 0236; 0245; 0246. . Retrieved 2020/03/29.
• 3、 -. "4-AMINO OR 4-ALKOXY-SUBSTITUTED ARYL SULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS". . . Retrieved 2020/07/05.