5-Amino-1,2,4-thiadiazole

Base Information

• Chemical Name: 5-Amino-1,2,4-thiadiazole
• CAS No.: 7552-07-0
• Molecular Formula: C2H3N3S
• Molecular Weight: 101.132
• Hs Code.: 2934999090
• Mol file: 7552-07-0.mol

Synonyms:1,2,4-Thiadiazole,5-amino- (7CI);(1,2,4-Thiadiazol-5-yl)amine;NSC153379;

Chemical Property of 5-Amino-1,2,4-thiadiazole

Chemical Property:

• Vapor Pressure: 0.0412mmHg at 25°C
• Melting Point: 112-115 °C
• Refractive Index: 1.662
• Boiling Point: 2.8 °C at 760 mmHg
• PKA: 3.97±0.50(Predicted)
• Flash Point: 98.3°C
• PSA: 80.04000
• Density: 0.692 g/cm³
• LogP: 0.70150
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

96% 1H NMR ^*data from raw suppliers

5-Amino-1,2,4-thiadiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
• Hazard Codes: Xi,Xn
• Statements: 20/22
• Safety Statements: S22:Do not inhale dust.; S36/37:Wear suitable protective clothing and gloves.

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Amino-1,2,4-thiadiazole is a useful research chemical for organic synthesis and other chemical processes.

Technology Process of 5-Amino-1,2,4-thiadiazole

There total 7 articles about 5-Amino-1,2,4-thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

2-amino-4-dimethylamino-1,3-thiazabuta-1,3-diene (943653-32-5) → 1,3,4-thiadiazol-5-amine (7552-07-0)

Guidance literature:

2-amino-4-dimethylamino-1,3-thiazabuta-1,3-diene; With hydroxylamine-O-sulfonic acid; In ethanol; at 80 ℃; for 8h;

With triethylamine; In ethanol; at 20 ℃; for 19h;

Reference yield:

formamidine acetic acid (3473-63-0) + potassium thioacyanate (333-20-0) → 1,3,4-thiadiazol-5-amine (7552-07-0)

Guidance literature:

formamidine acetic acid; potassium thioacyanate; In methanol; at 20 ℃; for 0.166667h;

With bromine; sodium methylate; In methanol; at -15 - 20 ℃; for 4h;

Reference yield:

5-amino-1,2,4-thiadiazole hydrochloride (152513-91-2) → 1,3,4-thiadiazol-5-amine (7552-07-0)

Guidance literature:

With potassium carbonate; In water; ethyl acetate;

DOI:10.1016/j.bmcl.2017.09.056

upstream raw materials:

N-chloro-formamidine

potassium thioacyanate

formamidine hydrochloride

methanol

Downstream raw materials:

N-[(2,4-dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine

5-(2,4,6-trimethyl-phenylazo)-[1,2,4]thiadiazole

2-(5-imino-[1,2,4]thiadiazol-4-yl)-1-(4-methoxy-phenyl)-ethanone

2-(5-imino-[1,2,4]thiadiazol-4-yl)-1-phenyl-ethanone

Refernces

• 1、 -. "HETEROCYCLIC DERIVATIVES AS MODULATORS OF ION CHANNELS". Page/Page column 14. . Retrieved 2009/05/28.
• 2、 -. "Heterocyclic derivatives as modulators of ion channels". Page/Page column 259. . Retrieved 2010/11/29.