L-2-Aminobutyric acid hydrochloride

Base Information

• Chemical Name: L-2-Aminobutyric acid hydrochloride
• CAS No.: 5959-29-5
• Molecular Formula: C4H9 N O2 . Cl H
• Molecular Weight: 139.582
• Mol file: 5959-29-5.mol

Synonyms:Butanoicacid, 2-amino-, hydrochloride, (2S)- (9CI); Butanoic acid, 2-amino-,hydrochloride, (S)-; Butyric acid, 2-amino-, hydrochloride, L- (8CI);(S)-2-Aminobutanoic acid hydrochloride; L-a-Amino-n-butyric acid hydrochloride

Chemical Property of L-2-Aminobutyric acid hydrochloride

Chemical Property:

• Vapor Pressure: 0.00811mmHg at 25°C
• Boiling Point: 247.7°C at 760 mmHg
• Flash Point: 103.6°C
• PSA: 63.32000
• LogP: 1.31060
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

(S)-2-AminobutanoicAcidHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (S)-2-Aminobutanoic Acid Hydrochloride is an intermediate in the synthesis of Levetiracetam (L331500), which is used as an anticonvulsant.

Technology Process of L-2-Aminobutyric acid hydrochloride

There total 7 articles about L-2-Aminobutyric acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

S-(+)-2-benzoylamino-n-butyric acid (87068-75-5) → S-(+)-2-amino-n-butyric acid hydrochloride (5959-29-5)

Guidance literature:

With hydrogenchloride; for 8h; Heating;

Reference yield: 80.0%

2-[(S)-1-(4-methoxyphenyl)ethylamino]-(S)-butyronitrile hydrochloride → S-(+)-2-amino-n-butyric acid hydrochloride (5959-29-5)

Guidance literature:

With hydrogenchloride; In water; at 90 ℃; for 4h;

Reference yield: 68.0%

(S)-N-benzoyl-3-methylalanine methyl ester (34047-84-2) → S-(+)-2-amino-n-butyric acid hydrochloride (5959-29-5)

Guidance literature:

With hydrogenchloride; In water; Reflux;

upstream raw materials:

(S)-ethyl 2-aminobutanoate

S-(+)-2-benzoylamino-n-butyric acid

<(1S,2R)-10-(N,N-dicyclohexylaminosulfonyl)born-2-yl> (2R)-2-aminobutyrate

(S)-2-aminobutyric acid methyl ester

Downstream raw materials:

n-propyl (2S)-2-trifluoroacetamidobutyrate

(S)-2-amino-butanamide

(S)-2-aminobutyric acid methyl ester hydrochloride

Boc-Tyr-Abu-OH

Refernces

• 1、 Raju, Veeramalla,Somaiah, Sripathi,Sashikanth, Suthrapu,Laxminarayan, Eppakayala,Mukkanti, Kagga. "An asymmetric synthesis of Levetiracetam". . p. 1218 - 1221. Retrieved 2014/12/10.
• 2、 Bull,Davies,Garner,O'Shea. "Conjugate additions of organocuprates to a 3-methylene-6-isopropyldiketopiperazine acceptor for the asymmetric synthesis of homochiral α-amino acids". . p. 3281 - 3287. Retrieved 2007/10/03.