2-benzyl-5,6-bis(diethoxyphosphorylmethyl)-1,1,3,3-tetraethylisoindoline

Base Information

• Chemical Name: 2-benzyl-5,6-bis(diethoxyphosphorylmethyl)-1,1,3,3-tetraethylisoindoline
• CAS No.: 1150647-61-2
• Molecular Formula: C₃₃H₅₃NO₆P₂
• Molecular Weight: 621.734
• Mol file: 1150647-61-2.mol

Synonyms:2-benzyl-5,6-bis(diethoxyphosphorylmethyl)-1,1,3,3-tetraethylisoindoline

Chemical Property of 2-benzyl-5,6-bis(diethoxyphosphorylmethyl)-1,1,3,3-tetraethylisoindoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzyl-5,6-bis(diethoxyphosphorylmethyl)-1,1,3,3-tetraethylisoindoline

There total 7 articles about 2-benzyl-5,6-bis(diethoxyphosphorylmethyl)-1,1,3,3-tetraethylisoindoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-benzyl-5,6-bis(bromomethyl)-1,1,3,3-tetraethylisoindoline (1150647-60-1) + triethyl phosphite (122-52-1) → 2-benzyl-5,6-bis(diethoxyphosphorylmethyl)-1,1,3,3-tetraethylisoindoline (1150647-61-2)

Guidance literature:

at 80 ℃; for 16h;

DOI:10.1002/ejoc.200801255

Reference yield:

2-benzoyl-1,1,3,3-tetraethylisoindoline-5,6-dicarboxylic acid (1150647-47-4) → 2-benzyl-5,6-bis(diethoxyphosphorylmethyl)-1,1,3,3-tetraethylisoindoline (1150647-61-2)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / diethyl ether / 72 h / Reflux

2: phosphorus tribromide / dichloromethane / 1.5 h / Inert atmosphere; Cooling with ice

3: 16 h / 80 °C

With lithium aluminium tetrahydride; phosphorus tribromide; In diethyl ether; dichloromethane;

Reference yield:

2-benzyl-1,1,3,3-tetraethyl-5,6-bis(hydroxymethyl)isoindoline (1150647-48-5) → 2-benzyl-5,6-bis(diethoxyphosphorylmethyl)-1,1,3,3-tetraethylisoindoline (1150647-61-2)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorus tribromide / dichloromethane / 1.5 h / Inert atmosphere; Cooling with ice

2: 16 h / 80 °C

With phosphorus tribromide; In dichloromethane;

upstream raw materials:

2-benzyl-5,6-bis(bromomethyl)-1,1,3,3-tetraethylisoindoline

triethyl phosphite

2-benzoyl-1,1,3,3-tetraethylisoindoline-5,6-dicarboxylic acid

2-benzyl-1,1,3,3-tetraethyl-5,6-bis(hydroxymethyl)isoindoline

Downstream raw materials:

2-benzyl-1,1,3,3-tetraethyl-5,6-bis(phosphonomethyl)isoindoline

Refernces

• 1、 -. "ANTIOXIDANT COMPOUNDS AND METHODS OF THEIR USE". Page/Page column 40. . Retrieved 2010/04/27.