Pyridine, 2-(chloromethyl)-5-methyl- (6CI,7CI,8CI,9CI)

Base Information

• Chemical Name: Pyridine, 2-(chloromethyl)-5-methyl- (6CI,7CI,8CI,9CI)
• CAS No.: 767-01-1
• Molecular Formula: C7H8ClN
• Molecular Weight: 141.6
• Hs Code.: 2933399090
• Mol file: 767-01-1.mol

Synonyms:2-(Chloromethyl)-5-methylpyridine;

Chemical Property of Pyridine, 2-(chloromethyl)-5-methyl- (6CI,7CI,8CI,9CI)

Chemical Property:

• Vapor Pressure: 0.253mmHg at 25°C
• Refractive Index: 1.527
• Boiling Point: 212.4 °C at 760 mmHg
• Flash Point: 102.2 °C
• PSA: 12.89000
• Density: 1.118 g/cm³
• LogP: 2.12880

Purity/Quality:

98%min ^*data from raw suppliers

2-(Chloromethyl)-5-methylpyridinehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyridine, 2-(chloromethyl)-5-methyl- (6CI,7CI,8CI,9CI)

There total 4 articles about Pyridine, 2-(chloromethyl)-5-methyl- (6CI,7CI,8CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-hydroxymethyl-5-methylpyridine (22940-71-2) → 5-methyl-pyridin-2-ylmethyl chloride (767-01-1)

Guidance literature:

2-hydroxymethyl-5-methylpyridine; With thionyl chloride; In methanol; for 0.0833333h; Heating / reflux;

With water; sodium hydrogencarbonate; In diethyl ether;

Reference yield: 38.0%

2,5-dimethylpyridine N-oxide (4986-05-4) → 5-methyl-pyridin-2-ylmethyl chloride (767-01-1)

Guidance literature:

2,5-dimethylpyridine N-oxide; With triethylamine; In dichloromethane; at 0 ℃; Inert atmosphere;

With bis(trichloromethyl) carbonate; In dichloromethane; Inert atmosphere;

DOI:10.1021/acs.joc.1c00749

Reference yield:

2-acetoxymethyl-5-methyl pyridine (772-71-4) → 5-methyl-pyridin-2-ylmethyl chloride (767-01-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 2N aq. NaOH / methanol / 2 h / 25 °C

2: SOCl₂ / CH₂Cl₂ / 2 h / 25 °C

With sodium hydroxide; thionyl chloride; In methanol; dichloromethane;

DOI:10.1021/jm00081a004

upstream raw materials:

2-hydroxymethyl-5-methylpyridine

2-acetoxymethyl-5-methyl pyridine

2,5-dimethylpyridine N-oxide

Downstream raw materials:

dl-1-[4-(5-methyl-pyridin-2-ylmethoxy)-phenyl]-2-(3,3-diphenylpropylamino)propane maleate

3-{3-tert-butylsulfanyl-5-(5-methyl-pyridin-2-ylmethoxy)-1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-1H-indol-2-yl}-2,2-dimethyl-propionic acid ethyl ester

2,5-dimethylpyridine

ethyl 2-(5-methylpyridin-2-yl)acetate

Refernces

• 1、 -. "NOVEL TETRAZOLE COMPOUNDS AND THEIR USE IN THE TREATMENT OF TUBERCULOSIS". Page/Page column 38. . Retrieved 2019/03/05.
• 2、 -. "COMPOSITIONS AND TREATMENTS COMPRISING 5-LIPOXYGENASE-ACTIVATING PROTEIN INHIBITORS AND NITRIC OXIDE MODULATORS". Page/Page column 102. . Retrieved 2008/12/06.