6-BROMO INDAZOLE-3-CARBOXYLIC ACID

Base Information

• Chemical Name: 6-BROMO INDAZOLE-3-CARBOXYLIC ACID
• CAS No.: 660823-36-9
• Molecular Formula: C8H5BrN2O2
• Molecular Weight: 241.04
• Hs Code.: 2933990090
• Mol file: 660823-36-9.mol

Synonyms:6-Bromo-1H-indazole-3-carboxylicacid;6-Bromoindazole-3-carboxylic acid;

Chemical Property of 6-BROMO INDAZOLE-3-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.766
• Boiling Point: 493.361 °C at 760 mmHg
• PKA: 2.74±0.10(Predicted)
• Flash Point: 252.176 °C
• PSA: 65.98000
• Density: 1.947 g/cm³
• LogP: 2.02360
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Bromo-1H-indazole-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Bromo-1H-indazole-3-carboxylic Acid is used in the synthesis of indazole derivatives as potent hepcidin production inhibitors for the treatment of anemia of chronic diseases (ACD).

Technology Process of 6-BROMO INDAZOLE-3-CARBOXYLIC ACID

There total 4 articles about 6-BROMO INDAZOLE-3-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

6-bromoisatin (6326-79-0) → 6-bromo-1H-indazole-3-carboxylic acid (660823-36-9)

Guidance literature:

6-bromoisatin; With sodium hydroxide; In water; at 20 - 50 ℃; for 1.5h;

With sulfuric acid; sodium nitrite; In water; at 0 ℃; for 0.75h;

With hydrogenchloride; tin(ll) chloride; In water; at 0 ℃; for 1.16667h;

Reference yield: 97.0%

6-bromo-1H-indazole-3-carboxylic acid methyl ester (885278-42-2) → 6-bromo-1H-indazole-3-carboxylic acid (660823-36-9)

Guidance literature:

With methanol; sodium hydroxide; at 80 ℃; for 2h;

Reference yield:

4-bromophenylglyoxylic acid (7099-87-8) → 6-bromo-1H-indazole-3-carboxylic acid (660823-36-9)

Guidance literature:

4-bromophenylglyoxylic acid; With hydrogenchloride; sodium nitrite; at 0 ℃;

With tin(II) chloride dihdyrate; In water; at 25 ℃; for 2h;

DOI:10.1016/j.ejmech.2020.112517

upstream raw materials:

6-bromoisatin

6-bromo-1H-indazole-3-carboxylic acid methyl ester

4-bromophenylglyoxylic acid

Downstream raw materials:

6-bromo-1H-indazole-3-carboxylic acid (4-fluorophenyl)amide

ethyl 6-bromo-1H-indazole-3-carboxylate

6-bromo-1-methyl-1H-indazole-3-carboxylic acid methyl ester

6-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)cyclopropyl)-1-methyl-1H-indazole-3-carboxylic acid

Refernces

• 1、 -. "INDAZOLE CARBOXAMIDES AS KINASE INHIBITORS". Page/Page column 31-32. . Retrieved 2021/04/10.
• 2、 Zhang, Mingliang,Fang, Xiaobao,Wang, Cong,Hua, Yi,Huang, Chen,Wang, Meng,Zhu, Lu,Wang, Zixu,Gao, Yuhan,Zhang, Tianyi,Liu, Haichun,Zhang, Yanmin,Lu, Shuai,Lu, Tao,Chen, Yadong,Li, Hongmei. "Design and synthesis of 1H-indazole-3-carboxamide derivatives as potent and selective PAK1 inhibitors with anti-tumour migration and invasion activities". . . Retrieved 2020/08/26.