METHYL 6-BROMO-1H-INDAZOLE-3-CARBOXYLATE

Base Information

• Chemical Name: METHYL 6-BROMO-1H-INDAZOLE-3-CARBOXYLATE
• CAS No.: 885278-42-2
• Molecular Formula: C₉H₇BrN₂O₂
• Molecular Weight: 255.071
• Hs Code.: 2933990090
• Mol file: 885278-42-2.mol

Synonyms:6-Bromo-1H-indazole-3-carboxylicacid methyl ester;methyl 6-bromo-1H-indazole-3-carboxylate;1H-indazole-3-carboxylic acid, 6-bromo-, methyl ester;

Chemical Property of METHYL 6-BROMO-1H-INDAZOLE-3-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.676
• Boiling Point: 399.674 °C at 760 mmHg
• PKA: 10.71±0.40(Predicted)
• Flash Point: 195.516 °C
• PSA: 54.98000
• Density: 1.71 g/cm³
• LogP: 2.11200
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl 6-bromo-1H-indazole-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 6-BROMO-1H-INDAZOLE-3-CARBOXYLATE

There total 5 articles about METHYL 6-BROMO-1H-INDAZOLE-3-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

methanol (67-56-1) + 6-bromo-1H-indazole-3-carboxylic acid (660823-36-9) → 6-bromo-1H-indazole-3-carboxylic acid methyl ester (885278-42-2)

Guidance literature:

With sulfuric acid; at 90 ℃; for 4h;

Reference yield:

6-bromo-1H-indazole-3-carboxylic acid (660823-36-9) → 6-bromo-1H-indazole-3-carboxylic acid methyl ester (885278-42-2)

Guidance literature:

With thionyl chloride; In methanol; at 60 ℃; for 1h;

Reference yield:

6-bromoisatin (6326-79-0) → 6-bromo-1H-indazole-3-carboxylic acid methyl ester (885278-42-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide; sodium nitrite; sulfuric acid / water / 0.17 h / 0 °C

1.2: 0 - 20 °C

2.1: sulfuric acid / 0 °C / Reflux

2.2: pH 7

With sulfuric acid; sodium hydroxide; sodium nitrite; In water;

upstream raw materials:

6-bromoisatin

methanol

6-bromo-1H-indazole-3-carboxylic acid

4-bromophenylglyoxylic acid

Downstream raw materials:

6-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)cyclopropyl)-1-methyl-1H-indazole-3-carboxylic acid

6-bromo-1H-indazole-3-carboxylic acid

Refernces

• 1、 -. "INDAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE". Page/Page column 51. . Retrieved 2013/03/26.
• 2、 -. "NOVEL FXR (NR1H4 ) BINDING AND ACTIVITY MODULATING COMPOUNDS". . . Retrieved 2011/04/13.