Cyclopropanecarboxamide,N-[2-(2-methoxy-1-naphthalenyl)ethyl]-

Base Information

• Chemical Name: Cyclopropanecarboxamide,N-[2-(2-methoxy-1-naphthalenyl)ethyl]-
• CAS No.: 156482-69-8
• Molecular Formula: C₁₇H₁₉NO₂
• Molecular Weight: 269.343
• Mol file: 156482-69-8.mol

Synonyms:

Chemical Property of Cyclopropanecarboxamide,N-[2-(2-methoxy-1-naphthalenyl)ethyl]-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s): Moderately toxic by ingestion.
• Hazard Codes: M
• Safety Statements: Moderately toxic by ingestion. When heated to decomposition it emits toxic vapors of NOx.:;"> x." target="_blank">Moderately toxic by ingestion. When heated to decomposition it emits toxic vapors of NOx.:

MSDS Files:

Useful:

Technology Process of Cyclopropanecarboxamide,N-[2-(2-methoxy-1-naphthalenyl)ethyl]-

There total 4 articles about Cyclopropanecarboxamide,N-[2-(2-methoxy-1-naphthalenyl)ethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

2-(2-methoxynaphthalen-1-yl)ethan-1-amine (156482-75-6) + cyclopropanecarboxylic acid chloride (4023-34-1) → N-<2-(2-methoxynaphthyl)ethyl>cyclopropylformamide (156482-69-8)

Guidance literature:

With triethylamine; In dichloromethane; for 0.5h; Ambient temperature;

DOI:10.1021/jm00012a004

Reference yield:

2-methoxy-1-naphthaldehyde (5392-12-1) → N-<2-(2-methoxynaphthyl)ethyl>cyclopropylformamide (156482-69-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / ammonium acetate / 2 h / Heating

2: 79 percent / LiAlH₄ / tetrahydrofuran / 24 h / 40 °C

3: 39 percent / Et₃N / CH₂Cl₂ / 0.5 h / Ambient temperature

With ammonium acetate; lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00012a004

Reference yield:

1-NITRO-2-(2-METHOXY-1-NAPHTHYL)ETHYLENE (116272-79-8) → N-<2-(2-methoxynaphthyl)ethyl>cyclopropylformamide (156482-69-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / LiAlH₄ / tetrahydrofuran / 24 h / 40 °C

2: 39 percent / Et₃N / CH₂Cl₂ / 0.5 h / Ambient temperature

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00012a004

upstream raw materials:

2-(2-methoxynaphthalen-1-yl)ethan-1-amine

cyclopropanecarboxylic acid chloride

2-methoxy-1-naphthaldehyde

1-NITRO-2-(2-METHOXY-1-NAPHTHYL)ETHYLENE

Refernces

• 1、 -. "ARYLALKYL (THIO) AMIDES". . . Retrieved 2008/06/13.