(1r,4r)-methyl 4-carbamoylcyclohexanecarboxylate

Base Information

• Chemical Name: (1r,4r)-methyl 4-carbamoylcyclohexanecarboxylate
• CAS No.: 1202-24-0
• Molecular Formula: C₉H₁₅NO₃
• Molecular Weight: 185.223
• Mol file: 1202-24-0.mol

Synonyms:(1r,4r)-methyl 4-carbamoylcyclohexanecarboxylate

Chemical Property of (1r,4r)-methyl 4-carbamoylcyclohexanecarboxylate

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1r,4r)-methyl 4-carbamoylcyclohexanecarboxylate

There total 3 articles about (1r,4r)-methyl 4-carbamoylcyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

trans-4-(methoxycarbonyl)cyclohexanecarboxylic acid (15177-67-0) + chloroformic acid ethyl ester (541-41-3) → (1r,4r)-methyl 4-carbamoylcyclohexanecarboxylate (1202-24-0)

Guidance literature:

trans-4-(methoxycarbonyl)cyclohexanecarboxylic acid; chloroformic acid ethyl ester; With triethylamine; In tetrahydrofuran; at -10 - 20 ℃; for 3h; Inert atmosphere;

With ammonium hydroxide; In tetrahydrofuran; at -10 - 20 ℃;

Reference yield: 46.0%

trans-4-(methoxycarbonyl)cyclohexanecarboxylic acid (15177-67-0) → (1r,4r)-methyl 4-carbamoylcyclohexanecarboxylate (1202-24-0)

Guidance literature:

trans-4-(methoxycarbonyl)cyclohexanecarboxylic acid; With 1,1'-carbonyldiimidazole; In ethyl acetate; at 20 ℃; for 1h;

With ammonium hydroxide; In water; ethyl acetate; at 0 - 20 ℃; for 16h;

Reference yield:

→ (1r,4r)-methyl 4-carbamoylcyclohexanecarboxylate (1202-24-0)

Guidance literature:

trans-4-Methoxycarbonyl-cyclohexancarbonsaeure, 1.) Chlorameisensaeure-ethylester, Et3N, 2.) NH3;

DOI:10.1021/ja01495a038

upstream raw materials:

trans-4-(methoxycarbonyl)cyclohexanecarboxylic acid

chloroformic acid ethyl ester

Downstream raw materials:

methyl trans-4-cyanocyclohexane-1-carboxylate

Refernces

• 1、 -. "DIHYDROPYRIMIDINE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES". Page/Page column 95. . Retrieved 2019/11/28.