Technology Process of (1R,2R)-methyl 1-((S)-2-(tert-butoxycarbonylamino)butanamido)-2-(4'-trifluoromethylbiphenyl-4-yl)cyclopropanecarboxylate
There total 5 articles about (1R,2R)-methyl 1-((S)-2-(tert-butoxycarbonylamino)butanamido)-2-(4'-trifluoromethylbiphenyl-4-yl)cyclopropanecarboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / toluene / Inert atmosphere; Reflux
2.1: methanol / 0.5 h / 0 - 20 °C
3.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C
3.2: 96 h / 50 °C / Inert atmosphere
4.1: hydrogenchloride / ethyl acetate; water / 0.5 h / 20 °C
5.1: chloroformic acid ethyl ester; 4-methyl-morpholine / dichloromethane / 0.5 h / 0 °C
5.2: 2 h / 20 °C
With
4-methyl-morpholine; hydrogenchloride; n-butyllithium; chloroformic acid ethyl ester; potassium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / toluene / Inert atmosphere; Reflux
2.1: methanol / 0.5 h / 0 - 20 °C
3.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C
3.2: 96 h / 50 °C / Inert atmosphere
4.1: hydrogenchloride / ethyl acetate; water / 0.5 h / 20 °C
5.1: chloroformic acid ethyl ester; 4-methyl-morpholine / dichloromethane / 0.5 h / 0 °C
5.2: 2 h / 20 °C
With
4-methyl-morpholine; hydrogenchloride; n-butyllithium; chloroformic acid ethyl ester; potassium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: methanol / 0.5 h / 0 - 20 °C
2.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C
2.2: 96 h / 50 °C / Inert atmosphere
3.1: hydrogenchloride / ethyl acetate; water / 0.5 h / 20 °C
4.1: chloroformic acid ethyl ester; 4-methyl-morpholine / dichloromethane / 0.5 h / 0 °C
4.2: 2 h / 20 °C
With
4-methyl-morpholine; hydrogenchloride; n-butyllithium; chloroformic acid ethyl ester;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;