cis-1-(1-piperidino)-2-(1-pyrrolidino)cyclohexane

Base Information

• Chemical Name: cis-1-(1-piperidino)-2-(1-pyrrolidino)cyclohexane
• CAS No.: 118207-31-1
• Molecular Formula: C₁₅H₂₈N₂
• Molecular Weight: 236.401
• Mol file: 118207-31-1.mol

Synonyms:cis-1-(1-piperidino)-2-(1-pyrrolidino)cyclohexane

Chemical Property of cis-1-(1-piperidino)-2-(1-pyrrolidino)cyclohexane

Chemical Property:

Purity/Quality:

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Technology Process of cis-1-(1-piperidino)-2-(1-pyrrolidino)cyclohexane

There total 2 articles about cis-1-(1-piperidino)-2-(1-pyrrolidino)cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

1-(1-pyrrolidino)-6-(1-piperidino)cyclohex-1-ene (118207-35-5) → cis-1-(1-piperidino)-2-(1-pyrrolidino)cyclohexane (118207-31-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; under 2068.6 Torr;

DOI:10.1021/jo00264a031

Reference yield:

α-N-piperidylcyclohexanone (3319-04-8) → cis-1-(1-piperidino)-2-(1-pyrrolidino)cyclohexane (118207-31-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / p-toluenesulfonic acid / benzene / 48 h / Heating

2: 62 percent / H₂ / 5percent Pd/C / ethyl acetate / 2068.6 Torr

With hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In ethyl acetate; benzene;

DOI:10.1021/jo00264a031

upstream raw materials:

1-(1-pyrrolidino)-6-(1-piperidino)cyclohex-1-ene

α-N-piperidylcyclohexanone

Refernces