3319-04-8

Basic information

• Product Name: 2-(piperidin-1-yl)cyclohexan-1-one
• Synonyms: 2-(piperidin-1-yl)cyclohexan-1-one;2-(1-Piperidinyl)cyclohexanone;2-(Piperidin-1-yl)cyclohexanone;2-Piperidinocyclohexanone;Einecs 222-017-4
• CAS NO: 3319-04-8
• Molecular Formula: C₁₁H₁₉NO
• Molecular Weight: 181.27466
• EINECS: 222-017-4
• Mol File: 3319-04-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 278.9°Cat760mmHg
• Flash Point: 114.4°C
• Appearance: /
• Density: 1.041g/cm³
• Vapor Pressure: 0.00414mmHg at 25°C
• Refractive Index: 1.514
• CAS DataBase Reference: 2-(piperidin-1-yl)cyclohexan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(piperidin-1-yl)cyclohexan-1-one(3319-04-8)
• EPA Substance Registry System: 2-(piperidin-1-yl)cyclohexan-1-one(3319-04-8)

Safety Data

• Hazardous Substances Data: 3319-04-8(Hazardous Substances Data)

Usage

General Description

2-(piperidin-1-yl)cyclohexan-1-one, also known as PCH, is a chemical compound with the molecular formula C11H19NO. It is a cyclic ketone that contains a piperidine ring, which gives it unique chemical properties. PCH is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and pharmaceutical compounds. It can also be used as a reagent in organic synthesis and as a precursor for the production of other chemical compounds. Additionally, PCH has potential applications in medical research, particularly in the development of new medications for the treatment of various neurological and psychiatric disorders.

InChI:InChI=1/C11H19NO/c13-11-7-3-2-6-10(11)12-8-4-1-5-9-12/h10H,1-9H2

Upstream product

• 7581-94-4 (+)-trans-(1-Piperidyl)cyclohexan-2-ol 
• 2981-10-4 1-(cyclohex-1-en-1-yl)piperidine 
• 110-89-4 piperidine 
• 533-60-8 cyclohexanone-2-ol 
• 822-87-7 2-Chlorocyclohexanone 
• 108-94-1 cyclohexanone 

Downstream Products

• 882409-09-8 (1S,2R)-2-(piperidin-1-yl)cyclohexanol 
• 118207-31-1 cis-1-(1-piperidino)-2-(1-pyrrolidino)cyclohexane 
• 7581-94-4 (+)-trans-(1-Piperidyl)cyclohexan-2-ol 
• 118207-35-5 1-(1-pyrrolidino)-6-(1-piperidino)cyclohex-1-ene 
• 7581-94-4 (+/-)-cis-2-Piperidino-cyclohexanol 
• 94824-44-9 1-phenyl-2-piperidin-1-yl-cyclohexanol 

Relevant articles and documents

Dynamic kinetic resolution allows a highly enantioselective synthesis of cis-α-aminocycloalkanols by ruthenium-catalyzed asymmetric hydrogenation

(Chemical Equation Presented) Resolutely dynamic hydrogenation: A highly efficient asymmetric hydrogenation of racemic N,N-disubstituted α-aminocycloalkanones involving dynamic kinetic resolution in the presence of a ruthenium catalyst gives chiral α-aminocycloalkanols with excellent enantioselectivities and cis diastereoselectivities (see scheme). A synthesis of optically pure U-(-)-50488 based on this reaction is reported.

Efficient Preparation of Cis Vicinal Tertiary Diamines from 2-Hydroxy Ketones in Two Steps

Cyclic (C5 and C6) cis vicinal tertiary diamines are efficiently prepared by catalytic hydrogenation, Pd(C), of the corresponding N-substituted amino enamines, e.g. 6.The latter are obtained by p-toluenesulfonic acid catalyzed condensation of secondary amines with cyclic 2-hydroxy ketones in refluxing benzene under Dean-Stark conditions or from the N-substituted 2-amino ketones.For example cis-1,2-dipyrrolidinocyclohexane has been obtained from adipoin in 69percent overall yield, isolated.