Technology Process of 7-(4-bromophenyl)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidine
There total 8 articles about 7-(4-bromophenyl)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
water; potassium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
1,2-dimethoxyethane;
at 70 ℃;
for 7h;
glass bomb;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: diisopropylamine / tetrahydrofuran; hexanes / 0.25 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
1.3: 0 °C
2.1: ethanol; sodium / copper(II) sulfate / 60 h / Reflux
2.2: pH 7
3.1: sodium hydrogencarbonate / water; dimethyl sulfoxide / 20 °C
4.1: water; tetrahydrofuran / 24 h / Reflux
4.2: 0.17 h / 20 °C
5.1: potassium hydroxide; water / methanol / 4 h / Reflux
5.2: pH 5
6.1: N,N-diethylaniline; trichlorophosphate / acetonitrile / 50 °C
7.1: potassium carbonate; water / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane / 7 h / 70 °C / glass bomb; Inert atmosphere
With
ethanol; water; sodium; sodium hydrogencarbonate; potassium carbonate; diisopropylamine; N,N-diethylaniline; potassium hydroxide; trichlorophosphate;
tetrakis(triphenylphosphine) palladium(0); copper(II) sulfate;
In
tetrahydrofuran; methanol; hexanes; 1,2-dimethoxyethane; water; dimethyl sulfoxide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.53 h / 0 - 20 °C
1.2: 0 - 20 °C
2.1: potassium carbonate; water / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane / 7 h / 70 °C / glass bomb; Inert atmosphere
With
water; sodium hydride; potassium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil;
