Multi-step reaction with 8 steps
1.1: diisopropylamine / tetrahydrofuran; hexanes / 0.25 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
1.3: 0 °C
2.1: ethanol; sodium / copper(II) sulfate / 60 h / Reflux
2.2: pH 7
3.1: sodium hydrogencarbonate / water; dimethyl sulfoxide / 20 °C
4.1: water; tetrahydrofuran / 24 h / Reflux
4.2: 0.17 h / 20 °C
5.1: potassium hydroxide; water / methanol / 4 h / Reflux
5.2: pH 5
6.1: N,N-diethylaniline; trichlorophosphate / acetonitrile / 50 °C
7.1: potassium carbonate; water / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane / 7 h / 70 °C / glass bomb; Inert atmosphere
8.1: potassium phosphate; water / tris-(dibenzylideneacetone)dipalladium(0); XPhos / isopropyl alcohol / 4 h / 100 °C / Inert atmosphere
With
potassium phosphate; ethanol; water; sodium; sodium hydrogencarbonate; potassium carbonate; diisopropylamine; N,N-diethylaniline; potassium hydroxide; trichlorophosphate;
tris-(dibenzylideneacetone)dipalladium(0); tetrakis(triphenylphosphine) palladium(0); copper(II) sulfate; XPhos;
In
tetrahydrofuran; methanol; hexanes; 1,2-dimethoxyethane; water; dimethyl sulfoxide; isopropyl alcohol; acetonitrile;