Acetamide,2,2,2-trifluoro-N-[2-(2-methoxy-1-naphthalenyl)-1-methylethyl]-

Base Information

• Chemical Name: Acetamide,2,2,2-trifluoro-N-[2-(2-methoxy-1-naphthalenyl)-1-methylethyl]-
• CAS No.: 156482-80-3
• Molecular Formula: C₁₆H₁₆F₃NO₂
• Molecular Weight: 311.304
• Mol file: 156482-80-3.mol

Synonyms:

Chemical Property of Acetamide,2,2,2-trifluoro-N-[2-(2-methoxy-1-naphthalenyl)-1-methylethyl]-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Safety Statements: Low toxicity by ingestion. When heated to decomposition it emits toxic vapors of NOx and F&minu"> x and F−." target="_blank">Low toxicity by ingestion. When heated to decomposition it emits toxic vapors of NOx and F&minu

MSDS Files:

Useful:

Technology Process of Acetamide,2,2,2-trifluoro-N-[2-(2-methoxy-1-naphthalenyl)-1-methylethyl]-

There total 4 articles about Acetamide,2,2,2-trifluoro-N-[2-(2-methoxy-1-naphthalenyl)-1-methylethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

1-(2-methoxynaphthyl)-2-aminopropane (156482-76-7) + trifluoroacetic anhydride (407-25-0) → N-<1-methyl-2-(2-methoxynaphthyl)ethyl>trifluoroacetamide (156482-80-3)

Guidance literature:

With pyridine; In dichloromethane; for 0.5h; Ambient temperature;

DOI:10.1021/jm00012a004

Reference yield:

2-methoxy-1-naphthaldehyde (5392-12-1) → N-<1-methyl-2-(2-methoxynaphthyl)ethyl>trifluoroacetamide (156482-80-3)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium acetate / 2 h / Heating

2: 59 percent / LiAlH₄ / tetrahydrofuran / 24 h / 40 °C

3: 34 percent / pyridine / CH₂Cl₂ / 0.5 h / Ambient temperature

With pyridine; ammonium acetate; lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00012a004

Reference yield:

(Z)-2-nitro-1-(2-methoxynaphthyl)propene (156482-77-8) → N-<1-methyl-2-(2-methoxynaphthyl)ethyl>trifluoroacetamide (156482-80-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / LiAlH₄ / tetrahydrofuran / 24 h / 40 °C

2: 34 percent / pyridine / CH₂Cl₂ / 0.5 h / Ambient temperature

With pyridine; lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00012a004

upstream raw materials:

1-(2-methoxynaphthyl)-2-aminopropane

trifluoroacetic anhydride

2-methoxy-1-naphthaldehyde

(Z)-2-nitro-1-(2-methoxynaphthyl)propene

Refernces

• 1、 -. "ARYLALKYL (THIO) AMIDES". . . Retrieved 2008/06/13.