Z-Gln-Pheol

Base Information

• Chemical Name: Z-Gln-Pheol
• CAS No.: 96235-69-7
• Molecular Formula: C₂₂H₂₇N₃O₅
• Molecular Weight: 413.473
• Mol file: 96235-69-7.mol

Synonyms:Z-Gln-Pheol

Chemical Property of Z-Gln-Pheol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Z-Gln-Pheol

There total 2 articles about Z-Gln-Pheol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

Cbz-L-Gln (2650-64-8) + L-Phenylalaninol (3182-95-4) → Z-Gln-Pheol (96235-69-7)

Guidance literature:

With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; 1.) 2 min., -15 deg C, 2.) 30 min., r.t.;

DOI:10.1002/hlca.19900730103

Reference yield: 71.0%

L-Phenylalaninol (3182-95-4) + Nα-carbobenzoxy-L-glutamine α-N-succinimidyl ester (34078-85-8) → Z-Gln-Pheol (96235-69-7)

Guidance literature:

In N,N-dimethyl-formamide; for 36h; Ambient temperature;

DOI:10.1248/cpb.38.2997

Reference yield: 95.0%

Z-Gln-Pheol (96235-69-7) → H-Gln-Pheol (79638-59-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 5h;

DOI:10.1248/cpb.38.2997

upstream raw materials:

Cbz-L-Gln

L-Phenylalaninol

N^α-carbobenzoxy-L-glutamine α-N-succinimidyl ester

Downstream raw materials:

H-Gln-Pheol

Boc-γ-benzyl-Glu-Gln-Phol

H-Glu(OBzl)-Gln-Phl*CF₃COOH

L-Gln-L-Gln-L-Phl

Refernces

• 1、 Iida,Yoshimatsu,Sanekata,Fujita. "Fungal metabolites. IV. Synthesis of an antibiotic peptide, trichosporin B-V, from Trichoderma polysporum". . p. 2997 - 3003. Retrieved 2007/10/02.