L-Gln-L-Gln-L-Phl

Base Information

• Chemical Name: L-Gln-L-Gln-L-Phl
• CAS No.: 96235-57-3
• Molecular Formula: C₁₉H₂₉N₅O₅
• Molecular Weight: 407.47
• Mol file: 96235-57-3.mol

Synonyms:L-Gln-L-Gln-L-Phl

Chemical Property of L-Gln-L-Gln-L-Phl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-Gln-L-Gln-L-Phl

There total 4 articles about L-Gln-L-Gln-L-Phl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

Z-L-Gln-L-Gln-L-Phl (96235-61-9) → L-Gln-L-Gln-L-Phl (96235-57-3)

Guidance literature:

With hydrogen bromide; In acetic acid; for 2h;

DOI:10.1248/cpb.38.2997

Reference yield:

Z-Gln-Pheol (96235-69-7) → L-Gln-L-Gln-L-Phl (96235-57-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / H₂ / 10percent Pd-C / methanol / 5 h

2: 73 percent / dimethylformamide / 72 h / Ambient temperature

3: 83 percent / 30percent HBr / acetic acid / 2 h

With hydrogen bromide; hydrogen; palladium on activated charcoal; In methanol; acetic acid; N,N-dimethyl-formamide;

DOI:10.1248/cpb.38.2997

Reference yield:

H-Gln-Pheol (79638-59-8) → L-Gln-L-Gln-L-Phl (96235-57-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NMM, isobutyl chloroformate / 1.) DMF, -20 deg C, 15 min; 2.) -10 deg C, 30 min; than to RT

2: 51 percent / acetic acid, H₂ / Pd/C / 3 h / 0 °C

With 4-methyl-morpholine; hydrogen; acetic acid; isobutyl chloroformate; palladium on activated charcoal;

upstream raw materials:

Z-L-Gln-L-Gln-L-Phl

Cbz-L-Gln

H-Gln-Pheol

Z-Gln-Pheol

Downstream raw materials:

L-Pro-L-Val-Aib-Aib-L-Gln-L-Gln-L-Phl

Boc-L-Pro-L-Val-Aib-Aib-L-Gln-L-Gln-L-Phl

Z-Pro-Val-Aib-Aib-Gln-Gln-Pheol

Z-Aib-Val-Aib-Aib-Gln-Gln-Pheol

Refernces

• 1、 Katz, Ellen,Schmitt, Heribert,Aydin, Mitat,Koenig, Wilfried A.,Jung, Guenther. "The C-Terminal Heptapeptides of Suzukacillin A and Alamethicin F30 - Sequence, Conformation, and Synthesis". . p. 365 - 377. Retrieved 2007/10/02.